Talk:Methionine synthase

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Here is the PDF of a review on B12 enabled reactions: [1]

There is a related protein where the entire structure was solved:

If you don't want to watch the entire thing, skip ahead to 31:20

The paper is here.[1]

This has the N-terminal half of the protein, including the homocysteine binding domain.[2]

Reactivation: DOI:10.1073/pnas.0906132106

Some methionine synthases don't make use of the folate cycle.

Predicted entire structure

Escherichia coli reca protein-bound DNA (PDB entry 3rec)

Drag the structure with the mouse to rotate
  1. ↑ Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B(12)-dependent methyltransferase complex. Nature. 2012 Mar 14. doi: 10.1038/nature10916. PMID:22419154 doi:10.1038/nature10916
  2. ↑ Koutmos M, Pejchal R, Bomer TM, Matthews RG, Smith JL, Ludwig ML. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3286-91. Epub 2008 Feb 22. PMID:18296644

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