Talk:Phosphofructokinase (PFK)

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I don't understand this statement:

"The PFK reaction is strongly exergonic (irreversible) under physiological conditions and hence is one of the glycolytic pathway's rate-determining steps."

The fact that the reaction is strongly exergonic suggests that it should be extremely rapid, assuming the Hammond postulate. In the absence of the Hammond postulate, the speed of a reaction and its exergonicity are not causally related. Should that say "endergonic"? Cheers, mevans 02:55, 13 October 2010 (IST)

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Michael Evans

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