Tetanus toxin

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Glycosylated C-terminal domain of tetanus toxin heavy chain complex with phosphate (PDB code 1fv2)

3D structures of tetanus toxin

Updated on 19-April-2022


  1. Hatheway CL. Toxigenic clostridia. Clin Microbiol Rev. 1990 Jan;3(1):66-98. PMID:2404569
  2. Bizzini B. Tetanus Toxin. Microbiological Reviews.1979 June;43(2):224-236.[1]
  3. Mechanism of Action of Tetanospasmin (Dr. Arnab K Rana) [image on the internet]. 2005[updated 2005 Dec 26; cited 2011 Apr 20]. Available from: http://en.wikipedia.org/wiki/File:Mechanism_of_action_of_tetanospasmin.gif
  4. Lalli G, Schiavo G. Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR. J Cell Biol. 2002 Jan 21;156(2):233-9. Epub 2002 Jan 21. PMID:11807088 doi:10.1083/jcb.200106142
  5. Mocchetti I. Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins. Cell Mol Life Sci. 2005 Oct;62(19-20):2283-94. PMID:16158191 doi:10.1007/s00018-005-5188-y
  6. 6.0 6.1 Chen C, Fu Z, Kim JJ, Barbieri JT, Baldwin MR. Gangliosides as high affinity receptors for tetanus neurotoxin. J Biol Chem. 2009 Sep 25;284(39):26569-77. Epub 2009 Jul 14. PMID:19602728 doi:10.1074/jbc.M109.027391
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NW. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. J Biol Chem. 2001 Aug 24;276(34):32274-81. Epub 2001 Jun 19. PMID:11418600 doi:10.1074/jbc.M103285200

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