Function
Thioredoxin (Trx) is an enzyme which facilitates, in its reduced form, the reduction of proteins by cysteine thiol-disulfide exchange[1]. They contain a CXXC motif.
- Trx-1 is a mammalian cellular protein.
- Trx-2 is mitochondria-specific.
- Trx C,M,X,Y are found in prokaryotes.
- Trx F,H,O are found in eukaryotes.
Relevance
Serum Trx level is a predictor of steatohepatitis[2].
Disease
Trx is involved in a wide range of human diseases and conditions including cancer, viral diseases, aging, cardiac conditions and more[3].
Structural highlights
The is involved in the reduction of disulfide bonds in proteins[4]
3D Structures of Thioredoxin
Thioredoxin 3D structures