Thioredoxin Reductase

From Proteopedia

spinqualitylabelsall models Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry 3qfa) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Structural highlights 4 3D Structures of Thioredoxin Reductase Function Thioredoxin Reductase or glutaredoxin domain-containing protein (TrxR) is an enzyme which reduces thioredoxin using NADPH[1]. TrxR-1 is cystolic while TrxR-2 is mitochondrial. TrxR-3 is highly expressed in testis. For more details see: User:Sarah Abdalla/Thioredoxin Reductase Glucocorticoids Steroid Hormones and their receptors Disease Mutations in TrxR-2 are associated with familial glucocorticoid deficiency[2]. Structural highlights TrxR and Trx form an [3]. . Water molecules are shown as red spheres. 3D Structures of Thioredoxin Reductase Thioredoxin reductase 3D structures

References

1. ↑ Arner ES, Holmgren A. Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem. 2000 Oct;267(20):6102-9. PMID:11012661
2. ↑ Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. doi: 10.1210/jc.2013-3844. Epub, 2014 Mar 6. PMID:24601690 doi:http://dx.doi.org/10.1210/jc.2013-3844
3. ↑ Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537 doi:10.1038/ncomms1382