Function
Thyroid hormone receptors (TR) are expressed as 2 proteins: TRα and TRβ. TR is a ligand-dependent transcription factor that mediates the biological activity of the thyroid hormone (triiodo-thyronine). TR contains DNA-binding domain at the center and ligand-binding domain at the C-terminal.
See also Intracellular receptors
Disease
TRβ-deficient mice exhibit a deficit in auditory function[1]. Mutations in TRβ cause thyroid hormone resistance syndrome. Mutations in the TRα ar involved in dwarfism[2]. Loss of normal functions of TR by deletion or mutations could contribute to cancer development[3].
Relevance
Triiodothyroacetic acid (Triac) is used to suppress thyroid hormone resistance[4].
Structural highlights
The [5].
