Transferrin receptor

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Human transferrin receptor ectodomain dimer (grey and green) complex with transferrin N-lobe (pink and yellow) and C-lobe (cyan and magenta) and carbonate, 1suv

3D structures of transferrin receptor

Updated on 14-December-2020

Domains – apical 197-378; ectodomain 121-760

1cx8 – hTfR ectodomain – human
6y76 - hTfR apical domain
1de4 - hTfR ectodomain + hemochromatosis protein + β-2-microglobulin
1suv, 6soy, 6soz - hTfR ectodomain + transferrin
6okd - hTfR ectodomain + TfR-binding cysteine-dense peptide
6d03, 6d04, 6d05 - hTfR ectodomain + transferrin – Cryo EM
6gsr, 6h5i - hTfR ectodomain + ferritin heavy chain – Cryo EM
6s9j - hTfR ectodomain + PRE-GP-C
3s9l, 3s9m, 3s9n - hTfR ectodomain + transferrin N-lobe
2nsu - hTfR ectodomain in dog retrovirus – Cryo EM
3kas - hTfR ectodomain + Machupo virus GP1

References

  1. Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999 Apr;21(4):396-9. PMID:10192390 doi:http://dx.doi.org/10.1038/7727
  2. Cazzola M, Beguin Y, Bergamaschi G, Guarnone R, Cerani P, Barella S, Cao A, Galanello R. Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis. Br J Haematol. 1999 Sep;106(3):752-5. PMID:10468869

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