Function
Transthyretin (TTR) is a serum carrier of the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site[1]. For details see Tafamidis and Student Project 2 for UMass Chemistry 423 Spring 2015.
Disease
TTR mutations are associated with amyloid deposition[2]. Tafamidis is a medication which stabilises TTR and is used in treatment of TTR amyloidosis[3].
Structural highlights
[4].
3D structures of transthyretin
Transthyretin 3D structures