TrkB tyrosine kinase receptor

Function

TrkB tyrosine kinase receptor (TrkB) or BDNF/NT-3 growth factors receptor is part of the Trk tyrosine kinase receptors family which includes TrkA or (High affinity nerve growth factor receptor) and TrkC or NT-3 growth factor receptor which are responsible for mediating the trophic effects of the nerve growth factor family of neurotrophins. TrkB is activated by Brain-Derived Neurotrophic Factor (BDNF) and neurotrophin-4 (NT4)^[1]. TrkB pathway is vital in neural development and maintenance through differentiation and neurogenesis. See also Neurotrophin

Relevance

Impairment of the BDNF-TrkB pathway is suspected to underlie the early dysfunction and prominent degeneration of striatal neurons in Huntington Disease^[2]. TrkB inhibitors are novel therapeutic drugs for inflammation-related depression^[3]. TrkB is a marker and mediator of carcinogenesis and metastasis^[4]. Its expression changes in neuroblastoma cells on exposure to various treatments^[5].

Structural highlights

. TrkB and neutrotrophin-4/5 interact via a and via a ^[6].

3D structures of TrkB tyrosine kinase receptor

Updated on 20-August-2024

Domains: ligand-binding 283-385; kinase 543-838

References

1. ↑ Barbacid M. The Trk family of neurotrophin receptors. J Neurobiol. 1994 Nov;25(11):1386-403. doi: 10.1002/neu.480251107. PMID:7852993 doi:http://dx.doi.org/10.1002/neu.480251107
2. ↑ Nguyen KQ, Rymar VV, Sadikot AF. Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington's Disease. Front Cell Neurosci. 2016 Mar 9;10:37. doi: 10.3389/fncel.2016.00037. eCollection, 2016. PMID:27013968 doi:http://dx.doi.org/10.3389/fncel.2016.00037
3. ↑ Zhang JC, Yao W, Hashimoto K. Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets. Curr Neuropharmacol. 2016;14(7):721-31. PMID:26786147
4. ↑ Han L, Zhang Z, Qin W, Sun W. Neurotrophic receptor TrkB: Is it a predictor of poor prognosis for carcinoma patients? Med Hypotheses. 2007;68(2):407-9. doi: 10.1016/j.mehy.2006.05.038. Epub 2006 Sep , 27. PMID:17008023 doi:http://dx.doi.org/10.1016/j.mehy.2006.05.038
5. ↑ Edsjo A, Lavenius E, Nilsson H, Hoehner JC, Simonsson P, Culp LA, Martinsson T, Larsson C, Pahlman S. Expression of trkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. Lab Invest. 2003 Jun;83(6):813-23. PMID:12808116
6. ↑ Banfield MJ, Naylor RL, Robertson AG, Allen SJ, Dawbarn D, Brady RL. Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure. 2001 Dec;9(12):1191-9. PMID:11738045