TrkB tyrosine kinase receptor

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Human TrkB (yellow and pink) complex with neurotrophin-4/5 (cyan and green) and sulfate ions (PDB code 1hcf)

3D structures of TrkB tyrosine kinase receptor

Updated on 03-March-2021

Domains: ligand-binding 283-385; kinase 543-838

1wwb – hTrkB ligand-binding domain – human
1hcf – hTrkB ligand-binding domain + neurotrophin-4/5
5mo9 – hTrkB ligand-binding domain + antibody
4asz – hTrkB kinase domain
4at3, 4at4, 4at5 – hTrkB kinase domain + inhibitor


  1. Barbacid M. The Trk family of neurotrophin receptors. J Neurobiol. 1994 Nov;25(11):1386-403. doi: 10.1002/neu.480251107. PMID:7852993 doi:
  2. Nguyen KQ, Rymar VV, Sadikot AF. Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington's Disease. Front Cell Neurosci. 2016 Mar 9;10:37. doi: 10.3389/fncel.2016.00037. eCollection, 2016. PMID:27013968 doi:
  3. Zhang JC, Yao W, Hashimoto K. Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets. Curr Neuropharmacol. 2016;14(7):721-31. PMID:26786147
  4. Han L, Zhang Z, Qin W, Sun W. Neurotrophic receptor TrkB: Is it a predictor of poor prognosis for carcinoma patients? Med Hypotheses. 2007;68(2):407-9. doi: 10.1016/j.mehy.2006.05.038. Epub 2006 Sep , 27. PMID:17008023 doi:
  5. Edsjo A, Lavenius E, Nilsson H, Hoehner JC, Simonsson P, Culp LA, Martinsson T, Larsson C, Pahlman S. Expression of trkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. Lab Invest. 2003 Jun;83(6):813-23. PMID:12808116
  6. Banfield MJ, Naylor RL, Robertson AG, Allen SJ, Dawbarn D, Brady RL. Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure. 2001 Dec;9(12):1191-9. PMID:11738045

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