Function
Trypanothione reductase (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor[1].
Relevance
TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases like Chagas Disease caused by the parasites Trypanosoma and Leishmania[2].
Structural highlights
The contains residues which are part of the electron transfer function of the enzyme and the bound TPT substrate[3].
