Tubulin acetyltransferase

From Proteopedia

Se-Met human tubulin cetyltransferase complex with acetyl CoA and Cl- ion (green) (PDB code 4if5)

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3D structures of tubulin acetyltransferase

Updated on 23-December-2020

4pk2, 4pk3 – hTAT catalytic domain + Acetyl CoA + bisubstrate analog - human
4gs4, 4b5o, 4u9y, 4u9z, 3vwe, 4if5 – hTAT catalytic domain + Acetyl CoA
4b5p – hTAT catalytic domain (mutant) + Acetyl CoA
3vwd – hTAT catalytic domain + acetoacetyl CoA
4h6z, 4hkf, 4yrh – zTAT + Acetyl CoA – zebrafish
4h6u – zTAT (mutant) + Acetyl CoA

References

↑ Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R. Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19655-60. doi:, 10.1073/pnas.1209357109. Epub 2012 Oct 15. PMID:23071314 doi:10.1073/pnas.1209357109
↑ Kalebic N, Martinez C, Perlas E, Hublitz P, Bilbao-Cortes D, Fiedorczuk K, Andolfo A, Heppenstall PA. Tubulin acetyltransferase alphaTAT1 destabilizes microtubules independently of its acetylation activity. Mol Cell Biol. 2013 Mar;33(6):1114-23. doi: 10.1128/MCB.01044-12. Epub 2012 Dec, 28. PMID:23275437 doi:http://dx.doi.org/10.1128/MCB.01044-12
↑ Press ER, Shao Q, Kelly JJ, Chin K, Alaga A, Laird DW. Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss. J Biol Chem. 2017 Jun 9;292(23):9721-9732. doi: 10.1074/jbc.M116.770917. Epub, 2017 Apr 20. PMID:28428247 doi:http://dx.doi.org/10.1074/jbc.M116.770917
↑ Li L, Yang XJ. Tubulin acetylation: responsible enzymes, biological functions and human diseases. Cell Mol Life Sci. 2015 Nov;72(22):4237-55. doi: 10.1007/s00018-015-2000-5. Epub , 2015 Jul 31. PMID:26227334 doi:http://dx.doi.org/10.1007/s00018-015-2000-5
↑ Davenport AM, Collins LN, Chiu H, Minor PJ, Sternberg PW, Hoelz A. Structural and Functional Characterization of the alpha-Tubulin Acetyltransferase MEC-17. J Mol Biol. 2014 Jul 15;426(14):2605-16. doi: 10.1016/j.jmb.2014.05.009. Epub, 2014 May 17. PMID:24846647 doi:http://dx.doi.org/10.1016/j.jmb.2014.05.009