Tumor susceptibility gene 101

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Human tumor susceptibility gene 101 protein (grey) complex with GAG polyprotein peptide (green) (PDB code 1mp4)

3D structures of tumor susceptibility gene 101

Updated on 12-June-2022

Additional Resources

For additional information, see: Human Immunodeficiency Virus


  • Freed E. 2003. The HIV-Tsg101 Interface: recent advances in a budding field. Trends in Microbiology 11:56-59.
  • Liu F, Stephen Ag, Adamson C, Gousset K, Aman MJ, Freed EO, Fisher RJ, Burke TR, Jr. 2005. Hydrazone and Hydrazide-Containing N-Substituted Glycines as Peptoid Surrogates for Expedited Library Synthesis: Application to the Preparation of Tsg101-Directed HIV-1 Budding Antagonist. Org Lett 8:5163-5168.
  • Macias M, Wiesnera S, Sudolb M. 2002. WW and SH3 domains, two different scaffolds to recognize proline-rich ligands. Protein Domains 513:30-37.
  • Pornillos O, Alam S, Davis D, Sundquist W. 2002. Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. Nature Structural Biology 9:812–817.
  • Pornillos O, Higginson D, Stray K, Fisher R, Garrus J, Payne M, He G, Wang H, Morham S, Sundquist W. 2003. HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. The Journal of Cell Biology 162:425-434.
  • Sudol M, Recinos C, Abraczinskas J, Humbert J, Farooq A. 2005. WW or WoW: The domains in a Union of Bliss. Life 57:773-778.
  • Tavassoli A, Lu Q, Gam J, Pan H, Benkovic S, Cohen S. 2008. Inhibition of HIV Budding by a Genetically Selected Cyclic Peptide Targeting the Gag-TSG101 Interaction. American Chemical Society,Chemical Biology 3:757-764.
  • VerPlank L, Bouamr F, LaGrassa T, Agresta B, Kikonyogo A, Leis J, Carter C. 2001. Tsg101, a homolgue of ubiquitin-conjugating (E2) enzymes, binds the L domain of HIV type 1 Pr55Gag. Proceeding of the National Academy of Science 98:7724-7729.

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