User:Madison Unger/Sandbox 1

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Human Acyl-Coenzyme A

Functioning dimer of ACAT

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References

  1. Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 May;581(7808):329-332. doi: 10.1038/s41586-020-2280-2. Epub 2020 May, 13. PMID:32433610 doi:http://dx.doi.org/10.1038/s41586-020-2280-2
  2. Moorthy PS, Neelagandan K, Balasubramanian M, Ponnuswamy MN. Purification, Crystallization and Preliminary X-Ray Diffraction Studies on Goat (Capra hircus) Hemoglobin - A Low Oxygen Affinity Species. Protein Pept Lett. 2009;16(4):454-6. PMID:19356147
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338. doi: 10.1038/s41586-020-2290-0. Epub 2020 May, 13. PMID:32433614 doi:http://dx.doi.org/10.1038/s41586-020-2290-0
  4. 4.0 4.1 Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV Jr. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem. 1998 Oct 9;273(41):26755-64. doi: 10.1074/jbc.273.41.26755. PMID:9756919 doi:http://dx.doi.org/10.1074/jbc.273.41.26755
  5. 5.0 5.1 Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4
  6. Liu J, Chang CC, Westover EJ, Covey DF, Chang TY. Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. Biochem J. 2005 Oct 15;391(Pt 2):389-97. doi: 10.1042/BJ20050428. PMID:15992359 doi:http://dx.doi.org/10.1042/BJ20050428
  7. Rogers MA, Liu J, Song BL, Li BL, Chang CC, Chang TY. Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators. J Steroid Biochem Mol Biol. 2015 Jul;151:102-7. doi: 10.1016/j.jsbmb.2014.09.008., Epub 2014 Sep 12. PMID:25218443 doi:http://dx.doi.org/10.1016/j.jsbmb.2014.09.008
  8. Hartmann T, Kuchenbecker J, Grimm MO. Alzheimer's disease: the lipid connection. J Neurochem. 2007 Nov;103 Suppl 1:159-70. doi: 10.1111/j.1471-4159.2007.04715.x. PMID:17986151 doi:http://dx.doi.org/10.1111/j.1471-4159.2007.04715.x
  9. Li J, Gu D, Lee SS, Song B, Bandyopadhyay S, Chen S, Konieczny SF, Ratliff TL, Liu X, Xie J, Cheng JX. Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene. 2016 Dec 15;35(50):6378-6388. doi: 10.1038/onc.2016.168. Epub 2016 May , 2. PMID:27132508 doi:http://dx.doi.org/10.1038/onc.2016.168
  10. Rudel LL, Shelness GS. Cholesterol esters and atherosclerosis-a game of ACAT and mouse. Nat Med. 2000 Dec;6(12):1313-4. doi: 10.1038/82110. PMID:11100106 doi:http://dx.doi.org/10.1038/82110


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