User:R. Jeremy Johnson/Gamma Secretase

From Proteopedia

Jump to: navigation, search

Gamma Secretase

Human Gamma Secretase. This protease is made up of 4 subunits: NCT (blue), PS1 (green), APH-1 (pink), and PEN2 (yellow). (PDB code: 5FN2)

Drag the structure with the mouse to rotate


  1. 1.0 1.1 1.2 Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ. The amyloid-beta forming tripeptide cleavage mechanism of gamma-secretase. Elife. 2016 Aug 31;5. doi: 10.7554/eLife.17578. PMID:27580372 doi:
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Zhou R, Yang G, Guo X, Zhou Q, Lei J, Shi Y. Recognition of the amyloid precursor protein by human gamma-secretase. Science. 2019 Feb 15;363(6428). pii: science.aaw0930. doi:, 10.1126/science.aaw0930. Epub 2019 Jan 10. PMID:30630874 doi:
  3. 3.0 3.1 3.2 Yang G, Zhou R, Shi Y. Cryo-EM structures of human gamma-secretase. Curr Opin Struct Biol. 2017 Oct;46:55-64. doi: 10.1016/ Epub, 2017 Jul 17. PMID:28628788 doi:
  4. 4.0 4.1 4.2 Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y. An atomic structure of human gamma-secretase. Nature. 2015 Aug 17. doi: 10.1038/nature14892. PMID:26280335 doi:
  5. Kumar D, Ganeshpurkar A, Kumar D, Modi G, Gupta SK, Singh SK. Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452. doi: 10.1016/j.ejmech.2018.02.035. Epub , 2018 Feb 15. PMID:29477076 doi:

Student Contributors

Daniel Mulawa

Layla Wisser

Proteopedia Page Contributors and Editors (what is this?)

R. Jeremy Johnson

Personal tools