From Proteopedia

Mitochondrial Calcium Uniporter (MCU)

Mitochondrial Calcium Uniporter Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image This is a default text for your page Ryan Heumann/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Contents 1 Introduction 2 Function 3 Structure 3.1 Selectivity Filter 4 Disease 4.1 Diabetes 4.2 Cancer 4.3 Inflammation Introduction Calcium Function Reference practice [3] Structure Figure 1. The coolest image of this protein!!!! Selectivity Filter Disease Diabetes Cancer Inflammation This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

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1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
3. ↑ ^{3.0 3.1} Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
4. ↑ Lambert JP, Murray EK, Elrod JW. MCUB and mitochondrial calcium uptake - modeling, function, and therapeutic potential. Expert Opin Ther Targets. 2020 Feb 24:1-7. doi: 10.1080/14728222.2020.1732926. PMID:32093523 doi:http://dx.doi.org/10.1080/14728222.2020.1732926

Student Contributors

Ryan Heumann

Rieser Wells