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U5 snRNP

Human Spliceosomal Protein U5-15kD


  1. Stevens SW, Barta I, Ge HY, Moore RE, Young MK, Lee TD, Abelson J. Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae. RNA. 2001 Nov;7(11):1543-53. PMID:11720284
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Galej WP, Oubridge C, Newman AJ, Nagai K. Crystal structure of Prp8 reveals active site cavity of the spliceosome. Nature. 2013 Jan 31;493(7434):638-43. doi: 10.1038/nature11843. Epub 2013 Jan 23. PMID:23354046 doi:
  3. 3.0 3.1 O'Keefe RT, Newman AJ. Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing. EMBO J. 1998 Jan 15;17(2):565-74. doi: 10.1093/emboj/17.2.565. PMID:9430647 doi:
  4. Hahn D, Beggs JD. Brr2p RNA helicase with a split personality: insights into structure and function. Biochem Soc Trans. 2010 Aug;38(4):1105-9. doi: 10.1042/BST0381105. PMID:20659012 doi:
  5. Collins CA, Guthrie C. The question remains: is the spliceosome a ribozyme? Nat Struct Biol. 2000 Oct;7(10):850-4. doi: 10.1038/79598. PMID:11017191 doi:
  6. Maeder C, Kutach AK, Guthrie C. ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Nat Struct Mol Biol. 2009 Jan;16(1):42-8. doi: 10.1038/nsmb.1535. Epub 2008 Dec, 21. PMID:19098916 doi:
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Frank DN, Roiha H, Guthrie C. Architecture of the U5 small nuclear RNA. Mol Cell Biol. 1994 Mar;14(3):2180-90. PMID:8114748
  8. Nancollis V, Ruckshanthi JP, Frazer LN, O'Keefe RT. The U5 snRNA internal loop 1 is a platform for Brr2, Snu114 and Prp8 protein binding during U5 snRNP assembly. J Cell Biochem. 2013 Dec;114(12):2770-84. doi: 10.1002/jcb.24625. PMID:23857713 doi:

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Wally Novak

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