High mobility group protein
From Proteopedia
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| - | <StructureSection load='2gzk' size='340' side='right' caption='Rat | + | <StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''> |
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== Function == | == Function == | ||
| + | '''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulator transcription. HMG superfamilies differ by their DNA-binding domains.<br /> | ||
| + | * '''HMGA'''s bind via an AT-hook domain. For details on HMGA see [[HMGI(Y)]].<br /> | ||
| + | * '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br /> | ||
| + | * '''HMGN'''s bind via a nucleosome binding domain.<br /> | ||
== Disease == | == Disease == | ||
| + | Rearrangements of the HMGA2 gene were detected in human benign lipoma tumors<ref>PMID:11576996</ref>. | ||
== Relevance == | == Relevance == | ||
| + | Overexpression of HMGB1 is associated with cancer and is targeted for cancer therapy<ref>PMID:20123075</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 11:49, 21 March 2016
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3D Structures of high mobility group protein (HMG)
Updated on 21-March-2016
References
- ↑ Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev. 2007 Dec;220:35-46. PMID:17979838 doi:http://dx.doi.org/10.1111/j.1600-065X.2007.00574.x
- ↑ Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID:11576996
- ↑ Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):131-40. doi:, 10.1016/j.bbagrm.2009.11.014. PMID:20123075 doi:http://dx.doi.org/10.1016/j.bbagrm.2009.11.014
