Nerve growth factor

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<StructureSection load='2ifg' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='1www' size='340' side='right' caption='Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code [[1www]])' scene='84/845929/Cv/1'>
== Function ==
== Function ==
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'''Nerve growth factor''' (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions<ref>PMID:11520933</ref>.
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'''Nerve growth factor''' (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions<ref>PMID:11520933</ref>. NGF interacts with 2 transmembrane receptors - TrkA and p75.
== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the <scene name='84/845929/Cv/4'>receptor D-5 domain Ig-like structure</scene> flanking the <scene name='84/845929/Cv/5'>NGF homodimer</scene>. Various side chains form the <scene name='84/845929/Cv/10'>interactions between NGF and its receptor</scene> with a <scene name='84/845929/Cv/11'>totally buried NGF Arg residue forming the strongest one</scene><ref>PMID:10490030</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody - human<br />
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[[6yw8]] - hβ-NGF – human - NMR<br />
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[[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody<br />
[[2ifg]], [[1www]] - hβ-NGF + TrkA<br />
[[2ifg]], [[1www]] - hβ-NGF + TrkA<br />
[[1sg1]] - hβ-NGF + neutrophin receptor<br />
[[1sg1]] - hβ-NGF + neutrophin receptor<br />

Current revision

Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code 1www)

Drag the structure with the mouse to rotate

3D structures of nerve growth factor

Updated on 17-November-2021

6yw8 - hβ-NGF – human - NMR
4edk, 4edw, 5jz7 - hβ-NGF + antibody
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra

References

  1. ↑ Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:http://dx.doi.org/10.1146/annurev.neuro.24.1.1217
  2. ↑ Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:http://dx.doi.org/10.3389/fnins.2019.00533
  3. ↑ Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705

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Alexander Berchansky, Michal Harel

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