High mobility group protein

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(New page: <StructureSection load='2gzk' size='340' side='right' caption='Rat HMG1 tandem boxes complexed with DNA (PDB code 2gzk).' scene=''> '''High mobility group protein (HMG)''' is a chroma...)
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<StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
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<StructureSection load='2gzk' size='340' side='right' caption='Rat HMG1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
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'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulater transcription. For details see [[HMGI(Y)]].
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== Function ==
== Function ==
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'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulates transcription. HMG superfamilies differ by their DNA-binding domains.<br />
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* '''HMGA'''s bind via an AT-hook domain. For details on HMGA see [[HMGI(Y)]].<br />
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* '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br />
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* '''HMGN'''s bind via a nucleosome binding domain.<br />
== Disease ==
== Disease ==
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Rearrangements of the HMGA2 gene were detected in human benign lipoma tumors<ref>PMID:11576996</ref>.
== Relevance ==
== Relevance ==
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Overexpression of HMGB1 is associated with cancer and is targeted for cancer therapy<ref>PMID:20123075</ref>.
== Structural highlights ==
== Structural highlights ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*HMGA
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**[[2ezd]], [[2eze]], [[2ezf]], [[2ezg]] – hHMG-1 + DNA - human<br />
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*HMGB box 1 domain residues 1-84; tandem boxes domain residues 1-166
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**[[2yrq]] – hHMG-1 tandem boxes - human - NMR<br />
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**[[2rtu]] – hHMG-1 box 1 - NMR<br />
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**[[2ly4]] – hHMG-1 box domain + cellular tumor antigen p53 - NMR<br />
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**[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br />
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**[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
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**[[8i9m]] – hHMG-1 89-183 + RAGE – Cryo EM<br />
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**[[9cg9]] – hHMG-1 + nucleosome – Cryo EM<br />
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**[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br />
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**[[1j3d]] – pHMG-2 C terminal – pig - NMR<br />
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**[[1j3c]] – pHMG-2 C terminal (mutant) - NMR<br />
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**[[1j3x]] – pHMG-2 N terminal (mutant) - NMR<br />
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**[[1hme]], [[1hmf]] – rHMG-1 B domain – rat - NMR <br />
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**[[1aab]] – rHMG-1 A domain - NMR <br />
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**[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br />
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**[[2gzk]] – rHMG-1 tandem boxes + DNA <br />
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**[[5zdz]], [[5ze0]], [[5ze1]], [[5ze2]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse<br />
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**[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
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**[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br />
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**[[1hma]] – DmHMG-D DNA-binding domain – ''Drosophila melanogaster'' - NMR<br />
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**[[1qrv]] – DmHMG-D DNA-binding domain + DNA <br />
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**[[3nm9]] – DmHMG-D DNA-binding domain (mutant) + DNA <br />
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**[[8r1x]] – DmHMG-D DNA-binding domain + DNA - NMR<br />
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*HMG
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[[1hme]], [[1hmf]] – rHMG1 B domain – rat - NMR <br />
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**[[2mrc]] – HMG residues 17-99 – ''Plasmodium falciparum'' - NMR <br />
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[[1aab]] – rHMG1 A domain - NMR <br />
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}}
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[[1ckt]] – rHMG1 A domain + DNA <br />
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[[2gzk]] – rHMG1 tandem boxes + DNA <br />
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[[2yrq]] – hHMG1 tandem boxes - human - NMR<br />
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[[2rtu]] – hHMG1 box 1 - NMR<br />
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[[2ly4]] – hHMG1 box domain + cellular tumor antigen p53 - NMR<br />
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[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG1 box domain – chinese hamster - NMR <br />
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Rat HMGB1 tandem boxes complexed with DNA (PDB code 2gzk).

Drag the structure with the mouse to rotate

3D Structures of high mobility group protein (HMG)

Updated on 26-August-2025

References

  1. ↑ Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev. 2007 Dec;220:35-46. PMID:17979838 doi:http://dx.doi.org/10.1111/j.1600-065X.2007.00574.x
  2. ↑ Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID:11576996
  3. ↑ Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1 and cancer. Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):131-40. doi:, 10.1016/j.bbagrm.2009.11.014. PMID:20123075 doi:http://dx.doi.org/10.1016/j.bbagrm.2009.11.014

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