3e7c

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[[Image:3e7c.png|left|200px]]
 
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{{STRUCTURE_3e7c| PDB=3e7c | SCENE= }}
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==Glucocorticoid Receptor LBD bound to GSK866==
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<StructureSection load='3e7c' size='340' side='right'caption='[[3e7c]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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===Glucocorticoid Receptor LBD bound to GSK866===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3e7c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7C FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18952422}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=866:5-AMINO-N-[(2S)-2-({[(2,6-DICHLOROPHENYL)CARBONYL](ETHYL)AMINO}METHYL)-3,3,3-TRIFLUORO-2-HYDROXYPROPYL]-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE'>866</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7c OCA], [https://pdbe.org/3e7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7c RCSB], [https://www.ebi.ac.uk/pdbsum/3e7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7c ProSAT]</span></td></tr>
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[[3e7c]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7C OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
==See Also==
==See Also==
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*[[Glucocorticoid receptor|Glucocorticoid receptor]]
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*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018952422</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bledsoe, R K.]]
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[[Category: Large Structures]]
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[[Category: Madauss, K P.]]
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[[Category: Bledsoe RK]]
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[[Category: Mclay, I.]]
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[[Category: Madauss KP]]
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[[Category: Stewart, E L.]]
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[[Category: Mclay I]]
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[[Category: Williams, S P.]]
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[[Category: Stewart EL]]
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[[Category: Activator]]
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[[Category: Williams SP]]
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[[Category: Alternative initiation]]
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[[Category: Chromatin regulator]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Glucocorticoid receptor]]
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[[Category: Gr]]
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[[Category: Lipid-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Pseudohermaphroditism]]
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[[Category: Receptor]]
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[[Category: Steroid-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

Glucocorticoid Receptor LBD bound to GSK866

PDB ID 3e7c

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