3edc

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{{Seed}}
 
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[[Image:3edc.jpg|left|200px]]
 
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==Crystal Structure of a 1.6-hexanediol Bound Tetrameric Form of Escherichia coli Lac-repressor Refined to 2.1 Resolution==
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The line below this paragraph, containing "STRUCTURE_3edc", creates the "Structure Box" on the page.
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<StructureSection load='3edc' size='340' side='right'caption='[[3edc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3edc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EDC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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{{STRUCTURE_3edc| PDB=3edc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3edc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edc OCA], [https://pdbe.org/3edc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3edc RCSB], [https://www.ebi.ac.uk/pdbsum/3edc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3edc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI] Repressor of the lactose operon. Binds allolactose as an inducer.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3edc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3edc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the structure of a novel tetrameric form of the lactose repressor (LacI) protein from Escherichia coli refined to 2.1 A resolution. The tetramer is bound to 1.6-hexanediol present in the crystallization solution and the final R(free) for the structure is 0.201. The structure confirms previously reported structures on the monomer level. However, the tetramer is much more densely packed. This adds a new level of complexity to the interpretation of mutational effects and challenges details in the current model for LacI function. Several amino acids, previously associated with changes in function but unexplained at the structural level, appear in a new structural context in this tetramer which provides new implications for their function. Proteins 2009. (c) 2008 Wiley-Liss, Inc.
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===Crystal Structure of a 1.6-hexanediol Bound Tetrameric Form of Escherichia coli Lac-repressor Refined to 2.1 Resolution===
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Crystal structure of a 1.6-hexanediol bound tetrameric form of Escherichia coli Lac-repressor refined to 2.1 A resolution.,Stenberg KA, Vihinen M Proteins. 2008 Sep 30. PMID:19004002<ref>PMID:19004002</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3edc" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19004002}}, adds the Publication Abstract to the page
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*[[Lac repressor|Lac repressor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19004002 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19004002}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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3EDC is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDC OCA].
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[[Category: Large Structures]]
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[[Category: Stenberg KAE]]
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==Reference==
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Crystal structure of a 1.6-hexanediol bound tetrameric form of Escherichia coli Lac-repressor refined to 2.1 A resolution., Stenberg KA, Vihinen M, Proteins. 2008 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19004002 19004002]
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[[Category: Escherichia coli k12]]
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[[Category: Stenberg, K A.E.]]
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[[Category: Allosteric]]
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[[Category: Dna-binding]]
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[[Category: Lac-repressor]]
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[[Category: Repressor]]
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[[Category: Tetramer]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:39:21 2008''
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Current revision

Crystal Structure of a 1.6-hexanediol Bound Tetrameric Form of Escherichia coli Lac-repressor Refined to 2.1 Resolution

PDB ID 3edc

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