2xo2
From Proteopedia
(Difference between revisions)
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| - | [[Image:2xo2.png|left|200px]] | ||
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{{STRUCTURE_2xo2| PDB=2xo2 | SCENE= }} | {{STRUCTURE_2xo2| PDB=2xo2 | SCENE= }} | ||
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===HUMAN ANNEXIN V WITH INCORPORATED METHIONINE ANALOGUE AZIDOHOMOALANINE=== | ===HUMAN ANNEXIN V WITH INCORPORATED METHIONINE ANALOGUE AZIDOHOMOALANINE=== | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN]] Defects in ANXA5 are associated with susceptibility to pregnancy loss, recurrent, type 3 (RPRGL3) [MIM:[http://omim.org/entry/614391 614391]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:17339269</ref> | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN]] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | ||
==About this Structure== | ==About this Structure== | ||
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*[[Annexin|Annexin]] | *[[Annexin|Annexin]] | ||
*[[Cyclin|Cyclin]] | *[[Cyclin|Cyclin]] | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Budisa, N.]] | [[Category: Budisa, N.]] | ||
Revision as of 02:12, 25 March 2013
Contents |
HUMAN ANNEXIN V WITH INCORPORATED METHIONINE ANALOGUE AZIDOHOMOALANINE
Disease
[ANXA5_HUMAN] Defects in ANXA5 are associated with susceptibility to pregnancy loss, recurrent, type 3 (RPRGL3) [MIM:614391]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.[1]
Function
[ANXA5_HUMAN] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
About this Structure
2xo2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- ↑ Bogdanova N, Horst J, Chlystun M, Croucher PJ, Nebel A, Bohring A, Todorova A, Schreiber S, Gerke V, Krawczak M, Markoff A. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. Hum Mol Genet. 2007 Mar 1;16(5):573-8. Epub 2007 Mar 5. PMID:17339269 doi:10.1093/hmg/ddm017
