2xo2
From Proteopedia
(Difference between revisions)
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| - | + | ==HUMAN ANNEXIN V WITH INCORPORATED METHIONINE ANALOGUE AZIDOHOMOALANINE== | |
| - | + | <StructureSection load='2xo2' size='340' side='right' caption='[[2xo2]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[2xo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XO2 FirstGlance]. <br> |
| - | [[http://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN]] Defects in ANXA5 are associated with susceptibility to pregnancy loss, recurrent, type 3 (RPRGL3) [MIM:[http://omim.org/entry/614391 614391]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:17339269</ref> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZH:AZIDOHOMOALANINE'>AZH</scene></td></tr> | |
| - | ==Function== | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hvg|1hvg]], [[1hvd|1hvd]], [[1avr|1avr]], [[1anw|1anw]], [[1hak|1hak]], [[1avh|1avh]], [[1hve|1hve]], [[1hvf|1hvf]], [[1anx|1anx]], [[1sav|1sav]], [[2xo3|2xo3]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2xo2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN]] Defects in ANXA5 are associated with susceptibility to pregnancy loss, recurrent, type 3 (RPRGL3) [MIM:[http://omim.org/entry/614391 614391]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:17339269</ref> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN]] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | [[http://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN]] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | ||
| - | |||
| - | ==About this Structure== | ||
| - | [[2xo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XO2 OCA]. | ||
==See Also== | ==See Also== | ||
*[[Annexin|Annexin]] | *[[Annexin|Annexin]] | ||
*[[Cyclin|Cyclin]] | *[[Cyclin|Cyclin]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Budisa, N | + | [[Category: Budisa, N]] |
| - | [[Category: Debela, M | + | [[Category: Debela, M]] |
| - | [[Category: Goettig, P | + | [[Category: Goettig, P]] |
| - | [[Category: Merkel, L | + | [[Category: Merkel, L]] |
[[Category: Ion channel]] | [[Category: Ion channel]] | ||
[[Category: Membrane binding protein]] | [[Category: Membrane binding protein]] | ||
[[Category: Poptosis]] | [[Category: Poptosis]] | ||
Revision as of 11:41, 18 December 2014
HUMAN ANNEXIN V WITH INCORPORATED METHIONINE ANALOGUE AZIDOHOMOALANINE
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