Elongation factor 3D structures

3D structures of elongation factor

Updated on 20-May-2025

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• EF-Tu
  • 1ls2 – yEF + Phe-tRNA – yeast – Cryo EM
    
  • 1efm, 1efc, 1dg1, 2fx3, 1etu, 5mi3 – EcEF – Escherichia coli
    
  • 5mi8, 5mi9 – EcEF (mutant)
    
  • 1qzd – EcEF – Cryo EM
    
  • 3u2q – EcEF + drug
    
  • 1mj1 – EcEF + Phe-tRNA + S12 + S13 + L11 – Cryo EM
    
  • 3ep2 - EcEF + tRNA + S12 + L11 + 16SRRNA + 23SRRNA – Cryo EM
    
  • 8qhc - EcEF + tRNA + SidH + E3 ubiquitin protein ligase – Cryo EM
    
  • 1ttt, 1ob5 – TaEF + Phe-tRNA + GDPNP - Thermus aquaticus
    
  • 1b23 - TaEF + Cys-tRNA
    
  • 3wxm – ApEF + plethora protein – Aeropyrum pernix
    
  • 6ji2 - ApEF + plethora protein + AP2
    
  • 4h9g, 4lbv, 4lbw, 4lby, 4lbz, 4lc0 – TtEF – Thermus thermophilus
    
  • 4j0q – PpEF – Pseudomonas putida
    
  • 5w75 – EF – Thermotoga neapolitana
    
  • 8yly, 8ym3 – EF – Synechococcus elongatus
    
  • 5tbf – EF domain 2-3– Vibrio cholerae"
  • 5w76, 6htw, 6i8r, 7bbn – EF – synthetic
    
• EF-Tu complex with antibiotics
  • 1ob2 - yEF + Phe-tRNA + antibiotic
    
  • 4v8q - TtEF + antibiotic in 30S ribosome
    
  • 1ha3 - TtEF + antibiotic + GDP
    
  • 2c77, 2c78 - TtEF + antibiotic + GTP analog
    
  • 4v68 – TtEF + antibiotic in 70S ribosome – Cryo EM
    
  • 2bvn - EcEF + GDP
    NP + antibiotic
    
  • 1d8t, 2hcj, 2hdn, 3u6b, 3u6k, 4g5g, 5jbq, 8fr3 – EcEF + antibiotic
    
  • 7st7 – EcEF + antibiotic in 70S ribosome – Cryo EM
    
• EF-Tu complex with nucleotide
  • 1d2e – bEF + GDP – bovine
    
  • 6eze – EcEF + GDP derivative
    
  • 5opd – EcEF + GTP
    
  • 1exm – TtEF + GTP analog
    
  • 1eft – TaEF + GNP – Thermus aquaticus
    
  • 1tui – TaEF + GDP
    
  • 1jny, 1skq – SsEF + GDP – Sulfolobus solfataricus
    
  • 3wya – PhEF + GDP - Pyrococcus horikoshii
    
  • 6mij – AbEF + GDP – Acinetobacter baumannii
    
  • 6gfu – EF + GDP – synthetic
    
  • 7vok – MtEF + GDP – Mycobacterium tuberculosis
    
• EF-Tu complex with protein
  • 3vmf – ApEF + translation termination factor
    
  • 3wy9 – PhEF + L12
    
  • 4p3y – EcEF + thiol:disulfide interchange protein
    
  • 8qfs – EcEF + SidH + tRNA
    
  • 5i4r, 5i4q, 7vmc – EcEF + CDIA + CDII
    
  • 4zv4 – PaEF + TSE6 - Pseudomonas aeruginosa
    
  • 4iw3 – PpEF + prolyl hydroxylase
    
  • 5v7y – EF + prolyl hydroxylase – Bacillus anthracis
    
  • 8xi2 – EF in C* complex – Chlamydomonas reinhardtii – Cryo EM
    
• EF-Tu with EF-Ts
  • 1xb2 – bEF + EF-Ts - bovine
    
  • 1f60 – yEF + EF-Ts C terminal
    
  • 1g7c - yEF + EF-Ts C terminal + GDPNP
    
  • 1ije, 1ijf - yEF + EF-Ts C terminal + GDP
    
  • 2b7b - yEF + EF-Ts C terminal (mutant) + GDP
    
  • 2b7c - yEF + EF-Ts C terminal (mutant)
    
  • 1efu, 3agp, 3agq, 4pc1 – EcEF + EcEF-Ts
    
  • 3avt, 3avu , 3avv, 3avw, 3avx, 3avy, 3vnu , 3vnv, 4fwt – EcEF + EcEF-Ts + RNA
    
  • 3mmp – EcEF + EcEF-Ts + RNA replicase beta chain
    
  • 4q7j – EcEF + EcEF-Ts + Q beta replicase + S1
    
  • 4r71 – EcEF + EcEF-Ts + RNA polymerase β chain + S1
    
  • 4pc7 – EcEF + EcEF-Ts + antibiotic + GNP
    
  • 4pc2, 4pc3, 4pc6 – EcEF + EcEF-Ts + GDP derivative
    
  • 1aip - TtEF + TtEF-Ts - Thermus thermophilus
    
  • 7vmx – MtEF + MtEF-Ts
    
• EF-Tu in the ribosome
  • 7a5g, 7o9k – hEF in 80S mitoribosome + GMPPCP – Cryo EM
    
  • 3eq3, 3eq4, 5afi – EcEF in 80S ribosome – Cryo EM
    
  • 6wd2, 6wd3, 6wd4, 6wd5, 6wd6, 6wd7, 6wd8, 6wd9, 6wda – EcEF in 80S ribosome + GDP – Cryo EM
    
  • 4v6l, 4v6k, 4v69 - EcEF in 30S ribosome – Cryo EM
    
  • 5lzc, 5uyk, 5uyl, 5uym, 5uyn, 5uyp, 5uyq, 5wdt, 5we4, 5we6, 5wf0, 5wfk, 5wfs -  EcEF in 70S ribosome – Cryo EM
    
  • 5imq, 5imr, 6zmo -  EcEF in 70S ribosome + Nsp1– Cryo EM
    
  • 8g7p, 8g7q - EcEF in 70S ribosome + tRNA – Cryo EM
    
  • 1zc8, 3dwu – TtEF in 70S ribosome – Cryo EM
    
  • 7paj, 7pak, 7pao, 7paq, 7par, 7pha, 7pi4, 7pi9, 7pib, 7pip, 7pis, 7pit – MpEF in 70S ribosome – Mycoplasma pneumoniae - Cryo EM
    
  • 4v5g, 4v5l, 4v5p, 4v5q, 4v5r, 4v5s - TtEF in 70S ribosome
  • 8v9l – EF in 70S ribosome – Mycobacterium smegmatis - Cryo EM
    
• EF-SII
  • 1tfi – hEF – human – NMR
    
  • 3ndq - hEF domain II
    
  • 8a40 – hEF in RNA Pol II complex – Cryo EM
    
  • 1wjt – mEF N terminal – mouse – NMR
    
  • 8h6r – EF LW domain – Arabidopsis thaliana
    
  • 1enw – yEF domain II – NMR
    
  • 1eo0 - yEF domain I – NMR
    
  • 1pqv, 1y1v – yEF + RNA polymerase II
    
  • 1y1y, 3gtm – yEF + RNA polymerase II + RNA
    
  • 8uoq, 8uot – yEF + RNA polymerase II + RNA – Cryo EM
  • 2xex – SaEF – Staphylococcus aureus
    
  • 2m1h – TbEF PWWP domain – Trypanosoma brucei – NMR
    
  • 7xgw – TbEF LN domain
    
• EF-ELL2
  • 2e5n – hEF N2 domain - NMR
    
  • 5jw9 – hEF + AFF4 peptide
    
• EF-G
  • 1efg, 1elo, 1ktv, 1wdt, 2dy1 – TtEF
    
  • 4m1k, 4myt, 4myu – TtEF (mutant)
    
  • 1pn6, 3izp, 5ot7 – TtEF – Cryo EM
    
  • 1fnm, 2bm0, 2bm1 – TtEF (mutant)
    
  • 2bcw – TtEF + L11 + L7/L12
    
  • 2bv3 - TtEF (mutant) + GTP analog
    
  • 2j7k - TtEF (mutant) + GDP analog
    
  • 1dar, 2efg – TtEF + GDP
    
  • 1jqm, 1jqs – EcEF + L11 – Cryo EM
    
  • 4fn5 – PaEF
    
  • 5tv2 – EF – Vibrio vulnificus
    
  • 5ty0 – EF N terminal – Legionella pneumophila
    
  • 5vh6 – EF N terminal – Bacillus subtilis
    
  • 6b8d – EF N terminal – Haemophilus influenzae
    
  • 6not – EF – Rickettsia prowazekii
    
  • 6bk7 – EF N terminal – Enterococcus faecalis
    
  • 6n0i – PpEF 2
    
  • 7cdw – MtEF
    
  • 2xex – SaEF
    
  • 3zz0, 3zzt, 3zzu – SaEF (mutant)
    
  • 2mzw – SaEF domains III-V + FAR1
    
• EF-G in the ribosome
  • 4v6x, 6vlz, 6z6m, 6z6n, 7a5k, 7w59, 7w5a – hEF in 80S ribosome – Cryo EM
    
  • 6vmi – hEF in 80S mitoribosome – Cryo EM
    
  • 7l20 – hEF in 39S mitoribosome – Cryo EM
    
  • 7nsh – pEF in 39S ribosome – pig - Cryo EM
    
  • 6ydp, 6ydw – pEF in 55S ribosome – Cryo EM
    
  • 7oyd – rEF in 80S ribosome – Cryo EM
    
  • 4v6w – DmEF in 80S ribosome – Cryo EM
    
  • 4v8u, 4v5m, 4v5n, 4w29, 4wpo, 4wqf, 4wqu, 4wqy – TtEF in 70S ribosome
    
  • 2om7, 4v5f, 4v7c – TtEF in 70S ribosome – Cryo EM
    
  • 4v9h, 4v9j, 4v9k, 4v9l, 4v9m, 4v90 – TtEF in 30S ribosome
    
  • 4v9o, 4v9p – EcEF in 30S ribosome
    
  • 4v9d – EcEF in 30S ribosome + antibiotics – Cryo-EM
    
  • 1zn0, 2rdo, 3j0e, 3ja1, 4v6t, 4v9b, 7k51, 7k52, 7k54 – EcEF in 30S ribosome – Cryo-EM
    
  • 3j9z, 4v7b, 4v7d, 7k55, 7n2c, 7n2v, 7pjv, 7pjw, 7pjx, 7pjy, 7pjz, 7ssd, 7ssl, 7ssp, 7ug7, 9gha, 9ghc, 9ghd – EcEF in 70S ribosome – Cryo-EM
    
  • 7otc – EcEF in 70S ribosome + antibiotics – Cryo-EM
    
  • 8p2f, 8p2g, 8p2h – SaEF in 70S ribosome – Cryo-EM
    
• EF-GreA/GreB
  • 2pn0 – EF – Nitrosomonas europaea
    
  • 2p4v – EcEF-GreB
    
  • 1grj – EcEF-GreA
    
  • 6ri7, 6rin – EcEF-GreB + transcriptase + DNA + RNA – Cryo EM
    
• EF-NusA
  • 1wcl, 1wcn – EcEF C terminal – NMR
    
  • 2kwp - EcEF N terminal – NMR
    
  • 2jzb – EcEF + RNA polymerase subunit α - NMR
    
  • 9f9u - EF – Saccharolobus solfataricus
    
  • 9fjl – NusA2 – Sulfolobus acidocaldarius
    
• EF-P
  • 1ueb – TtEF
    
  • 4v6a – TtEF in 70S ribosome
    
  • 3oyy – PaEF
    
  • 6j7m – PaEF + EARP
    
  • 3tre – EF – Coxiella burnetii
    
  • 3a5z – EcEF + lysyl-tRNA synthetase
    
  • 6enj, 6enu – EcEF – Cryo EM
    
  • 1yby – EF – Clostridium thermocellum
    
  • 5j3b – AbEF
    
  • 6rji – SaEF
    
  • 6rk3 – SaEF - NMR
    
  • 6s8z – EF – Corynebacterium glutamicum
    
  • 5wxk – EF + EARP – Neisseria meningitidis
    
• EF-P-like
  • 8s8u – EcEFL
• EF-Ts
  • 2uz8 – hEF (mutant)
    
  • 1b64 – hEF guanine exchange factor domain – NMR
    
  • 2cp9 – hEF UBA domain – NMR
    
  • 1gh8 – EF – Methanobacterium thermoautotrophicum – NMR
    
  • 2yy3 – PhEF
    
  • 1tfe – TtEF
    
• EF-1
  • 8b6z, 9azs – hEF alpha in 80S ribosome – Cryo EM
    
  • 5dqs – hEF β+γ
    
  • 5jpo – hEF γ+δ
    
  • 1pbu – hEF γ C terminal (mutant) - NMR
    
  • 2mvm, 2mvn – hEF δ-1 CAR domain – NMR
    
  • 2n51 – hEF δ-1 C terminal – NMR
    
  • 5bmu – hEF ε-1 + Glu tRNA ligase
    
  • 5y6l – hEF ε-1 (mutant) + MetRS + AspRS + Glu/Pro tRNA ligase + P38
    
  • 5lzs – rEF α-1 in 80S ribosome+ drug – rabbit
    
  • 4c0s, 6ra9 – rEF α-2
    
  • 5o8w – yEF α+β
    
  • 1nhy – yEF γ N terminal
    
  • 7csl – PhEF α+β
    
• EF-1 homolog
  • 8b3d, 8b3f, 9bz0, 9er2, 9fd2 - hEFH in RNA pol II + TCR + RNA + DNA – Cryo EM
    
  • 8tvy - yEFH in RNA pol II + TCR + RNA + DNA – Cryo EM
    
  • 5xog - EFH in RNA pol II + Spt4/5 + RNA + DNA – Komagataella pastoris – Cryo EM
    
• EF-2
  • 1s1h, 4v4b - hEF in 40S ribosome – Cryo EM
    
  • 8xsx - hEF in 80S ribosome + tRNA + SERBP1 + drug – Cryo EM
    
  • 3j7p - pEF in 80S ribosome – Cryo EM
    
  • 4cxg, 4cxh - rEF in 40S ribosome – Cryo EM
    
  • 7ls1, 7ls2 - mEF in 80S ribosome – Cryo EM
    
  • 8q87 - EF in 80S ribosome + SERBP1 – chicken – Cryo EM
    
  • 4v6w - DmEF in 40S ribosome – Cryo EM
    
  • 7osm - yEF in 80S ribosome
    
  • 5jup, 5jus, 5jut, 5juu, 6gq1, 7osa, 8cku, 8cmj, 8t3e, 8t3f, 8xu8 - yEF in 80S ribosome – Cryo EM
    
  • 8yld, 8ylr – yEF-2 + EF-3 in 80S ribosome – Cryo EM
    
  • 8cdr, 8ceh, 8civ - yEF in 80S ribosome + antibiotic – Cryo EM
    
  • 8eub, 8evs, 8ewb - yEF in 80S ribosome + IRES – Cryo EM
    
  • 8evq, 8evr, 8t3a, 8t3b, 8t3c, 8t3d - yEF in 80S ribosome + IRES + antibiotic – Cryo EM
    
  • 8umh - yEF in pol II complex – Cryo EM
    
  • 1n0v – yEF
    
  • 1u2r – yEF + GDP
    
  • 1n0u, 2e1r, 2npf – yEF + antifungal drug
    
  • 1zm2, 1zm3, 1zm4, 1zm9, 3b78, 3b82, 3b8h, 2zit – yEF + exotoxin
    
  • 2p8w, 2p8x, 3dny, 6gqb, 6gqv - yEF in 80S ribosome – Cryo EM
    
  • 2p8y, 2p8z, 5juo- yEF+ antifungal drug in 80S ribosome – Cryo EM
    
  • 5h7j - PhEF
    
  • 5h7l - PhEF + L12
    
  • 5h7k - PhEF + GDP
    
  • 6u45 – MnEF + GMPPCP – Methanoperedens nitroreducens
    
  • 6u43, 6u44 – MnEF (mutant) + GMPPCP
    
  • 6q2d - EF + DPH2 – Methanobrevibacter smithii
    
• EF-3
  • 2ix3 – yEF
    
  • 2iwh – yEF + ADPNP
    
  • 2iw3 – yEF + ADP
    
  • 2ix8, 7b7d – yEF in 80S ribosome – Cryo EM
    
• EF-4 (lepA)
  • 2ywh, 2ywe, 2ywf, 2ywg - AalepA + nucleotide - Aquifex aeolicus
    
  • 3cb4 - EclepA
    
  • 3deg, 3jcd, 3jce - EclepA in 70S ribosome + GMPPNP – Cryo EM
    
  • 5j8b - TtlepA in 70S ribosome + GDPCP
    
  • 4w2e - TtlepA in 70S ribosome
    
• EF-SelB
  • 5izk, 5izl, 5izm – hEF + GDP derivative
    
  • 1lva – MtEF C terminal – Moorella thermoacetica
    
  • 2v9v – MtEF winged helix domain
    
  • 1wsu, 2uwm – MtEF + RNA
    
  • 2ply – MtEF (mutant) + RNA
    
  • 4zu9 - AaEF
    
  • 4aca – MmEF – Methanococcus maripaludis
    
  • 4acb – MmEF + GTP analog
    
  • 4ac9 – MmEF + GDP
    
  • 2pjp – EcEF + RNA
    
• EF-Spt4 + EF-Spt5
  • 3h7h – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273
    
  • 6gmh, 6gml – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM
    
  • 5oik – bEF-Spt4 + EF-Spt5 + RNA polymerase II
    
  • 7nkx, 7nky – yEF-Spt4 + EF-Spt5 + EF-Spt16 in RNA polymerase II elongation complex - CryoEM
    
  • 2exu – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375
    
  • 4zn3, 4zn1 – EF-Spt4 + EF-Spt5 – Methanocaldococcus jannaschii
    
  • 5xon, 5xog, 6ir9, 6j4w, 6j4x, 6j4y, 6j4z, 6j50, 6j51 – EF-Spt4 + EF-Spt5 + EF-Tfiis in RNA polymerase II elongation complex - Komagataella phaffii - Cryo EM
    
• EF-Spt5
  • 2e6z – hEF KOW2 motif residues 420-471 – NMR
    
  • 2do3 – hEF KOW3 motif residues 462-523 – NMR
    
  • 6eqy – hEF KOW4 motif residues 522-647 – NMR
    
  • 2e70 – hEF KOW5 motif residues 694-757 – NMR
    
  • 6er0 – hEF KOW6 motif residues 961-1087 – NMR
    
  • 2do3, 2e6z, 2e70 – hEF KOW motif residues 694-757 – NMR
    
  • 5ohq – hEF KOW6-KOW7 domain residues 939-1087
    
  • 5oho – hEF KOWX-KOW4 domain residues 536-646
    
  • 7okx, 7ol0 – pEF-Spt5 in RNA polymerase II transcription complex – Cryo EM
    
  • 4ytl – yEF KOW2-KOW3 domain residues 534-632
    
  • 4ytk – yEF KOW1-linker domain residues 382-511
    
  • 2exu – yEF
    
• EF-Spt6
  • 4z2n – hEF middle domain residues 644-930
    
  • 4z2m – hEF middle domain + histone H3.1 + histone H4
    
  • 6gme – hEF SH2 domain residues 1317-1334
    
  • 7oop, 7opc, 7opd – hEF-Spt6 in RNA polymerase II transcription complex – Cryo EM
    
  • 6ted, 7unc, 7und – pEF in RNA polymerase II transcription complex - CryoEM
    
  • 3psf, 3psi – yEF core domain residues 235-1259
    
  • 3psj, 3psk – yEF SH2 domain residues 1247-1451
    
  • 5vkl, 5vko – yEF SH2 domain + RPB1 peptide
    
  • 2l3t - yEF SH2 domain - NMR
    
  • 3oak – yEF + transcription factor IWS1
    
  • 3gxw, 3gxx, 3pjp – EF SH2 domain – Candida glabrata
    
  • 6qtc – CgEF SH2 domain + Tyr phosphorylated CTD – NMR
    
  • 2xp1 – EF SH2 domain – Antonospora locustae
    
• EF-Spt16
  • 5umu, 5umt, 5xm2 – hEF
    
  • 5e5b - hEF N-terminal
    
• EF-M2-1
  • 5nkx, 5noh – EF core domain – human respiratory cyncytial virus
    
• EF-TEFM mitochondrial
  • 5ol9 - hEF N-terminal
    
  • 5ol8 - hEF C-terminal
    
  • 5ola - hEF + RNA polymerase + RNA + DNA
    
• EF-CA150
  • 2dod, 2doe, 2dof, 2e71, 2kiq, 2kis – hEF FF domain – NMR
    
  • 3hfh – hEF FF domain
    
  • 2ysi– mEF WW domain - NMR
    
• Elongin A

• • 4hfx – hEloA F-box domain
    
  • 6zuz – hEloA N-terminal
    
• Elongin C
  • 5zb2 – yEloC + Rad7
    
  • 1hv2 - yEloC + von-Hippel Lindau disease tumor suppressor - NMR
    
• Elongin BC complex
  • 1lqb, 1lm8 – hEloBC + VHL + hypoxia inducible factor 1 α
    
  • 6i7q, 6i7r – hEloBC + VHL + hypoxia inducible factor 2 α
    
  • 7q2j, 8bb2, 8bb3, 8bb4, 8bb5 – hEloBC + VHL + WD repeat-containing protein 5
    
  • 7jto, 7jtp – hEloBC + VHL + WD repeat-containing protein 5 + inhibitor
    
  • 7znt – hEloBC + VHL + bromodomain-containing protein 4
    
  • 3zrc, 3ztc, 3ztd, 3zun, 4awj, 4b95, 4b9k, 4bks, 4bkt, 4w9l, 4w9k, 4w9j, 4w9i, 4w9h, 4w9g, 4w9f, 4w9e, 4w9d, 4w9c, 5nw2, 5nw1, 5nw0, 5nvz, 5nvy, 5nvx, 5nvw, 5nvv, 6fmi, 6fmj, 6fmk, 6gfy, 8c13 - hEloBC + VHL + inhibitor
    
  • 5t35, 6sis - hEloBC + VHL + BRD4
    
  • 7khh - hEloBC + VHL + BRD4 + inhibitor
    
  • 7s4e, 7z6l, 7z76, 7z77 - hEloBC + VHL + SMARCA2 + inhibitor<br /
  • 4wqo - hEloBC + VHL + cullin-2
    
  • 6hr2, 6hay, 6hax - hEloBC + VHL + transcription activator
    
  • 4ajy - hEloBC + hypoxia inducible factor peptide
    
  • 6gmr, 6gfx, 6bvb - hEloBC + VHL + hypoxia inducible factor peptide
    
  • 5n4w - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1
    
  • 4n9f - hEloBC + VIF+ cullin-5 + CBF
    
  • 2ma9 - hEloBC + VIF - NMR
    
  • 3zrf, 5lli, 6gmx, 6gmq, 6gmn, 6gfz - hEloBC + VHL
    
  • 6zhc - hEloBC + VHL + Bcl-2-like protein
    
  • 2c9w, 2izv, 2jz3, 5bo4 – hEloBC + suppressor of cytokine signaling
    
  • 6c5x, 6i4x, 6i5n, 6i5j 7m6t – hEloBC + suppressor of cytokine signaling + Gp130 peptide
    
  • 6i5n, 6i5j – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide
    
  • 6i4x – hEloBC + suppressor of cytokine signaling + erythropoietin peptide
    
  • 6p59 - hEloBC + virion infectivity factor + CBF b
    
  • 3zkj - hEloBC + ankyrin rep
    
  • 1vcb – hEloBC + VHL
    
  • 3zng – hEloBC + ASB-9
    
  • 6v9h – hEloBC + creatine kinase + ASB-9 – Cryo EM
    
  • 6r6h, 6r7f, 6r7h, 6r7i, 6r7n – hEloBC in signalosome – Cryo EM
    
  • 2fnj - mEloBC + GUSTAVUS

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