Glucocorticoids

spinqualitylabelsall models Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry 3g6r) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Glucocorticoid receptor Forkhead box proteins (FOX) are transcription factors involved in regulation of gene expression.. FOXO1 activation contributes to glucocorticoid-induced beta cell death. FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. Human FoxO1 DNA-binding domain with DNA, Ca+2 and Cl- ions. Ca coordination site. Water molecules shown as red spheres. Cl coordination site. Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors. NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response. NCOA2 is a DNA transcription coactivator with glucocorticoid receptor. NCOA/STAT6 transactivator domain LXXLL peptide interactions. 1st Iod coordination site. 2nd Iod coordination site. Water molecules are shown as red spheres. 3th and 4th Iod coordination sites. 5th Iod coordination site. Thioredoxin Reductase (TrxR) is an enzyme which reduces thioredoxin using NADPH. Mutations in TrxR-2 are associated with familial glucocorticoid deficiency. Thioredoxin Reductase (TrxR) is an enzyme which reduces thioredoxin using NADPH. TrxR-2 is mitochondrial. For more details see User:Sarah Abdalla/Thioredoxin Reductase. TrxR and Trx form an intramolecular Cys-Cys bond. FAD binding site. Water molecules are shown as red spheres. Microsomal Prostaglandin E synthase (PGES) converts cyclooxygenase (COX)-derived prostaglandin to PGE2. It is membrane-associated and belongs to the microsomal glutathione S-transferase family. PGES is preferentially linked with the inducible COX-2 . PGES is induced by proinflammatory stimuli and down-regulated by anti-inflammatory glucocorticoids. Microsomal Prostaglandin E synthase is membrane-associated (coordinates are from OPM database. The anti-inflammatory inhibitor binds to PGES in a pocket above the glutathione and interacts with various side-chains of a helix. Water molecules are shown as red spheres. See also: Nuclear receptor

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