Cytochrome P450 3D structures: Difference between revisions

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
* human P450 1 family  
* human P450 1 family  
**[[2hi4]] – hP4501A2+naphthoflavone - human<br />
**[[2hi4]] – hP4501A2+naphthoflavone - human<br />
**[[4i8v]] - hP4501A1 +naphthoflavone<br />
**[[4i8v]] - hP4501A1 +naphthoflavone<br />
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**[[6iq5]], [[6o5y]] - hP4501B1 + inhibitor<br />
**[[6iq5]], [[6o5y]] - hP4501B1 + inhibitor<br />
**[[6oyv]] - P4501B1 + estradiol - synthetic<br />
**[[6oyv]] - P4501B1 + estradiol - synthetic<br />
* human P450 2 family  
* human P450 2 family  
**[[2pg5]], [[2pg6]], [[2pg7]] – hP4502A6 (mutant)<br />
**[[2pg5]], [[2pg6]], [[2pg7]] – hP4502A6 (mutant)<br />
**[[1pq2]] - hP4502C8<br />
**[[1pq2]] - hP4502C8<br />
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**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
* human P450 2 family complex
* human P450 2 family complex
**[[3ebs]] – hP4502A6 (mutant)+phenacetin<br />
**[[3ebs]] – hP4502A6 (mutant)+phenacetin<br />
**[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
**[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br />
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**[[3t3z]] - hP4502E1 + pilocarpine<br />
**[[3t3z]] - hP4502E1 + pilocarpine<br />
**[[3czh]], [[3dl9]], [[3c6g]] – hP4502R1+vitamin D<br />
**[[3czh]], [[3dl9]], [[3c6g]] – hP4502R1+vitamin D<br />
* human P450 3 family  
* human P450 3 family  
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[5vcc]], [[5vcd]], [[4l3q]] - hP4503A4 (mutant) <br />
**[[5vcc]], [[5vcd]], [[4l3q]] - hP4503A4 (mutant) <br />
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**[[7mk8]] - hP4503A7 + dithiothreitol<br />
**[[7mk8]] - hP4503A7 + dithiothreitol<br />
**[[8gk3]] - hP4503A7 + substrate<br />
**[[8gk3]] - hP4503A7 + substrate<br />
* human P450 7 family  
* human P450 7 family  
**[[3dax]] – hP4507A1<br />
**[[3dax]] – hP4507A1<br />
**[[3sn5]] - hP4507A1 + cholest-4-en-3-one
**[[3sn5]] - hP4507A1 + cholest-4-en-3-one
*human P450 11 family
*human P450 11 family
**[[6m7x]], [[7e7f]] - hP450 CYP11B1 + drug<br />
**[[6m7x]], [[7e7f]] - hP450 CYP11B1 + drug<br />
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
**[[4dvq]] - hP450 CYP11B2 + corticosterone<br />
**[[4fdh]], [[7m8v]] - hP450 CYP11B2 + drug<br />
**[[4fdh]], [[7m8v]] - hP450 CYP11B2 + drug<br />
**[[4zgx]], [[6xz8]], [[6xz9]] - hP450 CYP11B2 + inhibitor<br />
**[[4zgx]], [[6xz8]], [[6xz9]] - hP450 CYP11B2 + inhibitor<br />
* human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase)
* human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase)
**[[5uys]], [[3ruk]], [[6chi]], [[6cir]], [[6ciz]], [[6wr0]], [[6ww0]] - hP450 C17 + abiraterone derivative<br />
**[[5uys]], [[3ruk]], [[6chi]], [[6cir]], [[6ciz]], [[6wr0]], [[6ww0]] - hP450 C17 + abiraterone derivative<br />
**[[4nkv]], [[6wr1]] - hP450 C17 (mutant) + abiraterone derivative<br />
**[[4nkv]], [[6wr1]] - hP450 C17 (mutant) + abiraterone derivative<br />
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**[[4nkx]], [[4nky]] - hP450 C17 (mutant) + progesterone derivative<br />
**[[4nkx]], [[4nky]] - hP450 C17 (mutant) + progesterone derivative<br />
**[[3swz]] - hP450 C17 + drug<br />
**[[3swz]] - hP450 C17 + drug<br />
* human P450 19 family (aromatase)
* human P450 19 family (aromatase)
**[[5jkv]] - hP45019A1<br />
**[[5jkv]] - hP45019A1<br />
**[[5jkw]] - hP45019A1 + testosterone<br />
**[[5jkw]] - hP45019A1 + testosterone<br />
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**[[3s7s]] - hP45019A1 + exemestane<br />
**[[3s7s]] - hP45019A1 + exemestane<br />
**[[4gl5]], [[4gl7]] - hP45019A1 + inhibitor
**[[4gl5]], [[4gl7]] - hP45019A1 + inhibitor
* human P450 46 family  
* human P450 46 family  
**[[2q9f]] – hP45046A1+cholesterol<br />
**[[2q9f]] – hP45046A1+cholesterol<br />
**[[2q9d]], [[2q9g]] - hP45046A1<br />
**[[2q9d]], [[2q9g]] - hP45046A1<br />
**[[2vn0]] – hP450105A1+troglitazone<br />
**[[2vn0]] – hP450105A1+troglitazone<br />
**[[2zby]] - hP450105A1 (mutant)
**[[2zby]] - hP450105A1 (mutant)
* P450 from  ''Mycobacterium tuberculosis'' or sterol 14-α demethylase; CYP121 is mycocyclosin synthase
* P450 from  ''Mycobacterium tuberculosis'' or sterol 14-α demethylase; CYP121 is mycocyclosin synthase
**[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br />
**[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br />
**[[2ci0]], [[2cib]], [[1u13]] - MtP450 CYP51 (mutant)<br />
**[[2ci0]], [[2cib]], [[1u13]] - MtP450 CYP51 (mutant)<br />
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**[[8amo]], [[8ckn]] - MtP450 CYP143A1<br />
**[[8amo]], [[8ckn]] - MtP450 CYP143A1<br />
**[[5hdi]] - MtP450 CYP144A1<br />
**[[5hdi]] - MtP450 CYP144A1<br />
* P450cam or camphor-5 momooxygenase
* P450cam or camphor-5 momooxygenase
**[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]], [[6wpl]] - PpP450cam - ''Pseudomona putida''<br />
**[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]], [[6wpl]] - PpP450cam - ''Pseudomona putida''<br />
**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]], [[6we6]], [[6wfl]] – PpP450cam (mutant) <br />
**[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]], [[6we6]], [[6wfl]] – PpP450cam (mutant) <br />
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**[[4c9l]] - NaP450cam + camphor + CN<br />
**[[4c9l]] - NaP450cam + camphor + CN<br />
**[[4c9o]] - NaP450cam (mutant) + camphor + CN<br />
**[[4c9o]] - NaP450cam (mutant) + camphor + CN<br />
* P450nor or NADP nitrous oxide-forming nitric-oxide reductase or nitric oxide reductase
* P450nor or NADP nitrous oxide-forming nitric-oxide reductase or nitric oxide reductase
**[[1cl6]], [[1rom]], [[5y5j]], [[5y5l]], [[1jfb]], [[1jfc]], [[1ged]], [[1ehe]] – FoP450nor - ''Fusarium oxysporum''<br />
**[[1cl6]], [[1rom]], [[5y5j]], [[5y5l]], [[1jfb]], [[1jfc]], [[1ged]], [[1ehe]] – FoP450nor - ''Fusarium oxysporum''<br />
**[[2rom]] - FoP450nor+CO<br />
**[[2rom]] - FoP450nor+CO<br />
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**[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br />
**[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br />
**[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br />
**[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br />
*P450epoK
*P450epoK
**[[1q5e]] - ScP450epoK - ''Sorangium cellulosum''<br />
**[[1q5e]] - ScP450epoK - ''Sorangium cellulosum''<br />
**[[1q5d]], [[1pkf]] – ScP450epoK+epothilone <br />
**[[1q5d]], [[1pkf]] – ScP450epoK+epothilone <br />
*P450cin
*P450cin
**[[3bdz]], [[3be0]], [[4fyz]], [[4fb2]] – CbP450cin – ''Citrobacter braakii''<br />
**[[3bdz]], [[3be0]], [[4fyz]], [[4fb2]] – CbP450cin – ''Citrobacter braakii''<br />
**[[4lht]], [[4l77]] - CbP450cin (mutant)<br />
**[[4lht]], [[4l77]] - CbP450cin (mutant)<br />
**[[4fmx]], [[1t2b]] – CbP450cin + cineole<br />
**[[4fmx]], [[1t2b]] – CbP450cin + cineole<br />
**[[4l6g]] – CbP450cin (mutant) + cineole<br />
**[[4l6g]] – CbP450cin (mutant) + cineole<br />
* rabbit P450  
* rabbit P450  
**[[2bdm]] – rP450 CYP2B4 – rabbit<br />
**[[2bdm]] – rP450 CYP2B4 – rabbit<br />
**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]], [[5iut]], [[5iuz]], [[5em4]], [[6bww]] - rP450 CYP2B4 (mutant)<br />
**[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]], [[5iut]], [[5iuz]], [[5em4]], [[6bww]] - rP450 CYP2B4 (mutant)<br />
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**[[1nr6]] – rP450 CYP2C5+diclofenac<br />
**[[1nr6]] – rP450 CYP2C5+diclofenac<br />
**[[1n6b]] - rP450 CYP2C5+sulfaphenazole
**[[1n6b]] - rP450 CYP2C5+sulfaphenazole
*P450 BM3 or bifunctional P450/NADPH-P450 reductase; Domains – heme 1-458; FMN 459-647; FAD 659-1049
*P450 BM3 or bifunctional P450/NADPH-P450 reductase; Domains – heme 1-458; FMN 459-647; FAD 659-1049
**[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]], [[8q2f]] – PmP450 heme domain – ''Priestria megaterium''<br />
**[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]], [[8q2f]] – PmP450 heme domain – ''Priestria megaterium''<br />
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]], [[8dsg]], [[8qze]], [[8qzf]] - PmP450 heme domain (mutant)<br />
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]], [[8dsg]], [[8qze]], [[8qzf]] - PmP450 heme domain (mutant)<br />
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**[[7f3h]] - P450 heme domain – ''Deinococcus aerius''<br />
**[[7f3h]] - P450 heme domain – ''Deinococcus aerius''<br />
**[[7f3w]] - P450 heme domain – ''Deinococcus apachensis''<br />
**[[7f3w]] - P450 heme domain – ''Deinococcus apachensis''<br />
*Eukaryote P450 Cyp51 or lanosterol 14-alpha demethylase
*Eukaryote P450 Cyp51 or lanosterol 14-alpha demethylase
**[[3juv]] – hCyp51<br />
**[[3juv]] – hCyp51<br />
**[[3jus]], [[3ld6]], [[4uhi]], [[4uhl]] – hCyp51 + drug<br />
**[[3jus]], [[3ld6]], [[4uhi]], [[4uhl]] – hCyp51 + drug<br />
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**[[5tz1]] – CaP450 CYP51 + drug <br />
**[[5tz1]] – CaP450 CYP51 + drug <br />
**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
*Bacterial P450 Cyp51 or lanosterol 14-alpha demethylase
*Bacterial P450 Cyp51 or lanosterol 14-alpha demethylase
**[[6mi0]], [[7jj1]]– McP450 CYP51 – ''Methylcoccus capsulatus''<br />
**[[6mi0]], [[7jj1]]– McP450 CYP51 – ''Methylcoccus capsulatus''<br />
**[[7tef]] – MmP450 CYP51B1 – ''Mycobacterium marinum''<br />
**[[7tef]] – MmP450 CYP51B1 – ''Mycobacterium marinum''<br />
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**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
**[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br />
**[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br />
* Other CYPs  
* Other CYPs  
**[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
**[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br />
**[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
**[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br />
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**[[7qan]], [[8u3n]] - MiP450 – ''Micromonospora maris''<br />
**[[7qan]], [[8u3n]] - MiP450 – ''Micromonospora maris''<br />
**[[8ukz]] - MiP450 (mutant)<br />
**[[8ukz]] - MiP450 (mutant)<br />
*Other CYPs complexes
*Other CYPs complexes
**[[2rfc]] – PtP450+phenylimidazole<br />
**[[2rfc]] – PtP450+phenylimidazole<br />
**[[3wec]] – ReP450 + dihydroxy-aurachin Re <br />
**[[3wec]] – ReP450 + dihydroxy-aurachin Re <br />

Latest revision as of 09:41, 29 March 2026

3D Structures of Cytochrome P450

Updated on 29-March-2026

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Openfox

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