2oar

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Mechanosensitive Channel of Large Conductance (MscL)

Structural highlights

2oar is a 5 chain structure with sequence from Mycobacterium tuberculosis H37Ra. This structure supersedes the now removed PDB entry 1msl. The November 2008 RCSB PDB Molecule of the Month feature on Mechanosensitive Channels by David Goodsell is 10.2210/rcsb_pdb/mom_2008_11. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.5Å
Ligands:AU
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MSCL_MYCTA Channel that opens in response to stretch forces in the membrane lipid bilayer. The force required to trigger channel opening depends on the nature of the membrane lipids; the presence of phosphatidylinositol enhances mechanosensitivity of the channel. May participate in the regulation of osmotic pressure changes within the cell.[UniProtKB:P9WJN5]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

Contents


PDB ID 2oar

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Proteopedia Page Contributors and Editors (what is this?)

OCA, Eric Martz, David S. Goodsell, Eran Hodis

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