4af8

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The structural basis for metacaspase substrate specificity and activation

Structural highlights

4af8 is a 1 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.4Å
Ligands:CL, NA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MCA2_TRYB2 Cysteine protease that cleaves specifically after arginine or lysine residues.[1] [2]

See Also

References

  1. ↑ Moss CX, Westrop GD, Juliano L, Coombs GH, Mottram JC. Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing. FEBS Lett. 2007 Dec 11;581(29):5635-9. PMID:18005666 doi:10.1016/j.febslet.2007.11.009
  2. ↑ Machado MF, Marcondes MF, Juliano MA, McLuskey K, Mottram JC, Moss CX, Juliano L, Oliveira V. Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2. FEBS J. 2013 Jun;280(11):2608-21. PMID:23506317 doi:10.1111/febs.12248

Contents


PDB ID 4af8

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OCA

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