4bpl

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rice importin_alpha in complex with nucleoplasmin NLS

Structural highlights

4bpl is a 2 chain structure with sequence from Oryza sativa and Xenopus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IMA1A_ORYSJ Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.[1] [2]

See Also

References

  1. ↑ Jiang CJ, Imamoto N, Matsuki R, Yoneda Y, Yamamoto N. Functional characterization of a plant importin alpha homologue. Nuclear localization signal (NLS)-selective binding and mediation of nuclear import of nls proteins in vitro. J Biol Chem. 1998 Sep 11;273(37):24083-7. PMID:9727027
  2. ↑ Jiang CJ, Shoji K, Matsuki R, Baba A, Inagaki N, Ban H, Iwasaki T, Imamoto N, Yoneda Y, Deng XW, Yamamoto N. Molecular cloning of a novel importin alpha homologue from rice, by which constitutive photomorphogenic 1 (COP1) nuclear localization signal (NLS)-protein is preferentially nuclear imported. J Biol Chem. 2001 Mar 23;276(12):9322-9. Epub 2000 Dec 20. PMID:11124253 doi:http://dx.doi.org/10.1074/jbc.M006430200

Contents


PDB ID 4bpl

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OCA

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