4v8q

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Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome

Structural highlights

4v8q is a 10 chain structure with sequence from Thermus thermophilus HB8. This structure supersedes the now removed PDB entries 4abr and 4abs. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.1Å
Ligands:GDP, KIR, MG, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RL29_THET8 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.[HAMAP-Rule:MF_00374]

Publication Abstract from PubMed

In bacteria, ribosomes stalled at the end of truncated messages are rescued by transfer-messenger RNA (tmRNA), a bifunctional molecule that acts as both a transfer RNA (tRNA) and a messenger RNA (mRNA), and SmpB, a small protein that works in concert with tmRNA. Here, we present the crystal structure of a tmRNA fragment, SmpB and elongation factor Tu bound to the ribosome at 3.2 angstroms resolution. The structure shows how SmpB plays the role of both the anticodon loop of tRNA and portions of mRNA to facilitate decoding in the absence of an mRNA codon in the A site of the ribosome and explains why the tmRNA-SmpB system does not interfere with normal translation.

Decoding in the absence of a codon by tmRNA and SmpB in the ribosome.,Neubauer C, Gillet R, Kelley AC, Ramakrishnan V Science. 2012 Mar 16;335(6074):1366-9. PMID:22422985[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
27 reviews cite this structure
Arrest peptides: cis-acting modulators of translation.
Ito et al. (2013)
26 more
43 other articles
No citations found

See Also

References

  1. ↑ Neubauer C, Gillet R, Kelley AC, Ramakrishnan V. Decoding in the absence of a codon by tmRNA and SmpB in the ribosome. Science. 2012 Mar 16;335(6074):1366-9. PMID:22422985 doi:10.1126/science.1217039

Contents


PDB ID 4v8q

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