6g6x

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14-3-3sigma in complex with a P129beta3P mutated YAP pS127 phosphopeptide

Structural highlights

6g6x is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.13Å
Ligands:ACE, CL, EOE, NA, SEP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

1433S_HUMAN Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

Publication Abstract from PubMed

Here we describe the synthesis of a series of alpha,beta-phosphopeptides, based on the phosphoepitope site on YAP1 (yes-associated protein 1), and the biochemical, biophysical and structural characterization of their binding to 14-3-3 proteins. The impact of systematic mono- and di-substitution of alpha --> beta3 amino acid residues around the phosphoserine residue are discussed. Our results confirm the important role played by the +2 proline residue in the thermodynamics and structure of the phosphoepitope/14-3-3 interaction.

A study on the effect of synthetic alpha-to-beta(3)-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins.,Andrei SA, Thijssen V, Brunsveld L, Ottmann C, Milroy LG Chem Commun (Camb). 2019 Nov 25. doi: 10.1039/c9cc07982c. PMID:31763628[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Andrei SA, Thijssen V, Brunsveld L, Ottmann C, Milroy LG. A study on the effect of synthetic alpha-to-beta(3)-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem Commun (Camb). 2019 Nov 25. doi: 10.1039/c9cc07982c. PMID:31763628 doi:http://dx.doi.org/10.1039/c9cc07982c

Contents


PDB ID 6g6x

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OCA

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