7olg

From Proteopedia

EB1 bound to MACF peptide

Structural highlights

7olg is a 4 chain structure with sequence from Homo sapiens and Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MARE1_MOUSE Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). May play a role in cell migration (PubMed:15311282).[UniProtKB:Q15691]^[1]

References

↑ Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M, Wallar BJ, Alberts AS, Gundersen GG. EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat Cell Biol. 2004 Sep;6(9):820-30. Epub 2004 Aug 15. PMID:15311282 doi:http://dx.doi.org/10.1038/ncb1160

1 Structural highlights
2 Function
3 See Also
4 References

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PDB ID 7olg

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Categories: Homo sapiens | Large Structures | Mus musculus | Almeida TB | Barsukov IL

7olg

From Proteopedia

EB1 bound to MACF peptide

Structural highlights

Function

See Also

References

Contents

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