7uj2

From Proteopedia

Jump to: navigation, search

OspC Type K

Structural highlights

7uj2 is a 2 chain structure with sequence from Borreliella burgdorferi 297. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.503Å
Ligands:CL, EDO
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OSPC2_BORBG Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337]

See Also

Contents


PDB ID 7uj2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/7uj2"
Personal tools