Outer surface protein

From Proteopedia

Outer surface protein A (PDB entry 2af5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Outer surface proteins (Osp) are produced by the bacteria Borrelia burgdorferi which causes Lyme disease. OspA and OspB are upregulated when the bacteria enter the tick. OspA[1] contributes to the colonization of the gut by the bacteria. OspB[2], OspC[3] and OspE[4] are major antigens on the surface of the Lyme disease spirochetes when it is being transmitted to humans. For more details see: OspA - G09SecL04Tpc2 G1SecL05 OspA OspA L03 Group2 OspB - Outer surface protein B (OspB) of the Lyme disease spirochete bacterium G14secL04Tpc3 G04SecL04Tpc1 G15SecL05Tpc3 G13secL03Tpc3 G12SecL02Tpc3 OspC - OspC and Binding SB2013 L08gr01 G18secL03Tpc4. OxpA, OspB and OspC - Highlighted Proteins of Lyme Disease

3D structures of Outer surface proteins (Updated on 20-August-2023)

References

1. ↑ Pal U, de Silva AM, Montgomery RR, Fish D, Anguita J, Anderson JF, Lobet Y, Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J Clin Invest. 2000 Aug;106(4):561-9. PMID:10953031 doi:http://dx.doi.org/10.1172/JCI9427
2. ↑ Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathog. 2007 Mar;3(3):e33. PMID:17352535 doi:10.1371/journal.ppat.0030033
3. ↑ Carrasco SE, Troxell B, Yang Y, Brandt SL, Li H, Sandusky GE, Condon KW, Serezani CH, Yang XF. Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages. Infect Immun. 2015 Dec;83(12):4848-60. doi: 10.1128/IAI.01215-15. Epub 2015 Oct, 5. PMID:26438793 doi:http://dx.doi.org/10.1128/IAI.01215-15
4. ↑ Lam TT, Nguyen TP, Montgomery RR, Kantor FS, Fikrig E, Flavell RA. Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect Immun. 1994 Jan;62(1):290-8. PMID:8262642