7x5o

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Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly

Structural highlights

7x5o is a 2 chain structure with sequence from Enterococcus faecium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.62Å
Ligands:PLG, THH
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A133CK16_ENTFC Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]

See Also

Contents


PDB ID 7x5o

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OCA

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