Structural highlights
Function
PTH_NEIG2 The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Publication Abstract from PubMed
A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.
Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction.,Hassell-Hart S, Speranzini E, Srikwanjai S, Hossack E, Roe SM, Fearon D, Akinbosede D, Hare S, Spencer J Org Lett. 2022 Nov 4;24(43):7924-7927. doi: 10.1021/acs.orglett.2c02996. Epub, 2022 Oct 20. PMID:36265082[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Hassell-Hart S, Speranzini E, Srikwanjai S, Hossack E, Roe SM, Fearon D, Akinbosede D, Hare S, Spencer J. Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction. Org Lett. 2022 Nov 4;24(43):7924-7927. doi: 10.1021/acs.orglett.2c02996. Epub, 2022 Oct 20. PMID:36265082 doi:http://dx.doi.org/10.1021/acs.orglett.2c02996
