Activin

From Proteopedia

Contents 1 Function 2 Relevance 3 Structural highlights Function Activin A or inhibitin β chain A (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner[1]. See also TGF beta signaling pathway. Relevance There is a strong overexpression of activin A in inflammatory bowel disease[2]. Activin A plays an important role in chronic rhinosinusitis inflammation. Structural highlights Activin is synthesyzed as a large precursor and its pro domain is cleaved proteolitically releasing a mature domain[3].

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3D structures of activin

Updated on 08-September-2024

5hlz, 5hly - hActA - human
2arv - hActA mature domain residues 311-426
1nys, 1nyu, 1s4y - hActA mature domain + Acvr2B LBD
2b0u, 2arp, 2p6a - hActA mature domain + follistatin
3b4v - hActA mature domain + follistatin-like 3
6y6n, 6y6o - hActA mature domain + diazepine derivative
7u5o - hActB + BMPR-2

References

1. ↑ Burdette JE, Jeruss JS, Kurley SJ, Lee EJ, Woodruff TK. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Cancer Res. 2005 Sep 1;65(17):7968-75. doi: 10.1158/0008-5472.CAN-04-3553. PMID:16140969 doi:http://dx.doi.org/10.1158/0008-5472.CAN-04-3553
2. ↑ Hubner G, Brauchle M, Gregor M, Werner S. Activin A: a novel player and inflammatory marker in inflammatory bowel disease? Lab Invest. 1997 Oct;77(4):311-8. PMID:9354766
3. ↑ Wang X, Fischer G, Hyvonen M. Structure and activation of pro-activin A. Nat Commun. 2016 Jul 4;7:12052. doi: 10.1038/ncomms12052. PMID:27373274 doi:http://dx.doi.org/10.1038/ncomms12052