Function
Anthrax edema factor (EF) or calmodulin-sensitive adenylate cyclase is an enzyme which is part of the Bacillus anthracis anthrax toxin. The full anthrax toxin is composed of -
The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one.[1] See also Toxins.
Disease
The anthrax disease is caused by the invasion of cells by the bacteria followed by increasing the cellular level of cAMP thus upsetting water homeostasis and causing disruption of signaling pathways.
Structural highlights
- .
- of EF. Water molecules are shown as red spheres.
- of calmodulin (PDB code 1pk0).[2]
3D structures of anthrax edema factor
Anthrax edema factor 3D structures