Art:Dodecapod

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Image:7sya-rainbow.gif

Tailed bacteriophages and herpesviruses have a DNA "pipe" in their capsids, called a portal protein[1]. The images here depict 7sya, a homo-dodecamer[1]. In the animation at right, each of the 12 protein chains is colored amino to carboxy spectrum (N->C Rainbow):

N               C

All images show a model simplified to alpha carbons only. Except for the top row, the alpha carbons are rendered at an exaggerated diameter (6.0 Å) to give a solid appearance. All images and the animation were generated with FirstGlance in Jmol, most using color schemes available under Solid (Views tab). The two faces of the oblate structure (or tube with a flange) are designated the N-face (face with amino termini) and the C-face (face with carboxy termini).

Image:7sya-rainbow-trace-N.png
NImage:Arrow.gifC Rainbow, N-face.

Image:7sya-rainbow-trace-C.png
NImage:Arrow.gifC Rainbow, C-face.

Image:7sya-rainbow-N.png
NImage:Arrow.gifC Rainbow, N-face.

Image:7sya-rainbow-C.png
NImage:Arrow.gifC Rainbow, C-face.

Image:7sya-dist-N.png
Distance from center, C-face

Image:7sya-seq-N.png
12 sequence-identical chains, C-face

Image:7sya-ss-N.png
2° structure, N-face

Image:7sya-ss-C.png
2° structure, C-face

Image:7sya-ch-N.png
Chains are distinct colors, N-face

Image:7sya-ch-C.png
Chains are distinct colors, C-face

Image:7sya-gs-N.png
Distance from center, N-face

Image:7sya-gs-C.png
Distance from center, C-face


References & Notes

  1. ↑ 1.0 1.1 David Hou CF, Swanson NA, Li F, Yang R, Lokareddy RK, Cingolani G. Cryo-EM Structure of a Kinetically Trapped Dodecameric Portal Protein from the Pseudomonas-phage PaP3. J Mol Biol. 2022 Mar 9;434(9):167537. doi: 10.1016/j.jmb.2022.167537. PMID:35278476 doi:http://dx.doi.org/10.1016/j.jmb.2022.167537

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz

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