Beta-2 microglobulin
From Proteopedia
Beta-2 microglobulin (B2M) is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. [1] For more details, see: Human beta two microglobulin and Molecular playground/beta 2 microglobulin.
DiseaseElevated B2M levels are found in patients of liver cirrhosis[2] and hepatitis[3]. Dialysis-associated amyloidosis is a serious complication in chronic dialysis patients. It is caused by B2M fibrils amyloid deposits[4]. RelevanceB2M is used as a marker for certain types of blood cell cancer. It can indicate the spread and severity of myeloma. Structural HighlightsHuman β-2 microglobulin with MHC class I HLA-A2 and HCMV PP65 nonapeptide (3mrb). 3D Structures of β-2 microglobulinBeta-2 microglobulin 3D structures
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References
- ↑ Liu C, Sawaya MR, Eisenberg D. beta-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat Struct Mol Biol. 2011 Jan;18(1):49-55. Epub 2010 Dec 5. PMID:21131979 doi:10.1038/nsmb.1948
- ↑ Nyberg A, Loof L, Hallgren R. Serum beta 2-microglobulin levels in primary biliary cirrhosis. Hepatology. 1985 Mar-Apr;5(2):282-5. doi: 10.1002/hep.1840050222. PMID:3884477 doi:http://dx.doi.org/10.1002/hep.1840050222
- ↑ Okoror LE, Ajayi AO, Ijalana OB. Elevated serum beta2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria. BMC Res Notes. 2017 Dec 8;10(1):719. doi: 10.1186/s13104-017-3015-9. PMID:29221492 doi:http://dx.doi.org/10.1186/s13104-017-3015-9
- ↑ Drueke TB. Beta2-microglobulin and amyloidosis. Nephrol Dial Transplant. 2000;15 Suppl 1:17-24. doi:, 10.1093/oxfordjournals.ndt.a027958. PMID:10737162 doi:http://dx.doi.org/10.1093/oxfordjournals.ndt.a027958
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