Beta2 adrenergic receptor-Gs protein complex

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Adrenergic receptor (blue) complex with G protein α subunit (grey), β subunit (green), γ-2 subunit (gold), antibody fragment (Orchid) and benzoxazin derivative 3sn6, resolution 3.20Å

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References

  1. https://en.wikipedia.org/wiki/G_protein
  2. https://en.wikipedia.org/wiki/GTPase
  3. https://en.wikipedia.org/wiki/Small_GTPase
  4. https://en.wikipedia.org/wiki/Heterotrimeric_G_protein
  5. Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. DNA Res. 2000 Apr 28;7(2):111-20. doi: 10.1093/dnares/7.2.111. PMID:10819326 doi:http://dx.doi.org/10.1093/dnares/7.2.111
  6. Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. Crystal structure of the beta2 adrenergic receptor-Gs protein complex. Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361. PMID:21772288 doi:10.1038/nature10361
  7. doi: https://dx.doi.org/10.1126/science.278.5345.1943
  8. Markby DW, Onrust R, Bourne HR. Separate GTP binding and GTPase activating domains of a G alpha subunit. Science. 1993 Dec 17;262(5141):1895-901. doi: 10.1126/science.8266082. PMID:8266082 doi:http://dx.doi.org/10.1126/science.8266082
  9. Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL. Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9420-4. doi:, 10.1073/pnas.1105810108. Epub 2011 May 23. PMID:21606326 doi:http://dx.doi.org/10.1073/pnas.1105810108
  10. Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL Jr, Steyaert J, Kobilka BK, Sunahara RK, Skiniotis G. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16086-91. doi:, 10.1073/pnas.1113645108. Epub 2011 Sep 13. PMID:21914848 doi:http://dx.doi.org/10.1073/pnas.1113645108
  11. Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL Jr, Sunahara RK. Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor. Nature. 2011 Sep 28;477(7366):611-5. doi: 10.1038/nature10488. PMID:21956331 doi:10.1038/nature10488

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