User:Wayne Decatur/UNH BCHEM833 Structural Proteomics Introductory Lecture Fall 2012

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A Common Starting Point

Key Resources

Discussed Items

Molecular Visualization and Viewers

(Generally, arranged in order of increasing complexity:)

Example Structures Used or Discussed in Class

Notes and References

  1. Evans P. Biochemistry. Resolving some old problems in protein crystallography. Science. 2012 May 25;336(6084):986-7. PMID:22628641 doi:10.1126/science.1222162
  2. Karplus PA, Diederichs K. Linking crystallographic model and data quality. Science. 2012 May 25;336(6084):1030-3. PMID:22628654 doi:10.1126/science.1218231
  3. Liu Q, Dahmane T, Zhang Z, Assur Z, Brasch J, Shapiro L, Mancia F, Hendrickson WA. Structures from anomalous diffraction of native biological macromolecules. Science. 2012 May 25;336(6084):1033-7. PMID:22628655 doi:10.1126/science.1218753
  4. Kaya E, Doudna JA. Biochemistry. Guided tour to the heart of RISC. Science. 2012 May 25;336(6084):985-6. PMID:22628640 doi:10.1126/science.1223549
  5. Schirle NT, Macrae IJ. The Crystal Structure of Human Argonaute2. Science. 2012 Apr 26. PMID:22539551 doi:10.1126/science.1221551
  6. Tate CG. A crystal clear solution for determining G-protein-coupled receptor structures. Trends Biochem Sci. 2012 Sep;37(9):343-52. Epub 2012 Jul 10. PMID:22784935 doi:10.1016/j.tibs.2012.06.003
  7. Ledford, H. Consortium solves its 1,000th protein structure. Published online 30 September 2010. Nature doi:10.1038/news.2010.500
  8. Lee D, de Beer TA, Laskowski RA, Thornton JM, Orengo CA. 1,000 structures and more from the MCSG. BMC Struct Biol. 2011 Jan 10;11:2. PMID:21219649 doi:10.1186/1472-6807-11-2
  9. Drew K, Winters P, Butterfoss GL, Berstis V, Uplinger K, Armstrong J, Riffle M, Schweighofer E, Bovermann B, Goodlett DR, Davis TN, Shasha D, Malmstrom L, Bonneau R. The Proteome Folding Project: proteome-scale prediction of structure and function. Genome Res. 2011 Nov;21(11):1981-94. Epub 2011 Aug 8. PMID:21824995 doi:10.1101/gr.121475.111
  10. I don't see SCOP (Structural Clasification of Proteins) listed there but is listed in analysis towards top of the page.
  11. Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. Crystal structure of the beta2 adrenergic receptor-Gs protein complex. Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361. PMID:21772288 doi:10.1038/nature10361
  12. Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL Jr, Sunahara RK. Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor. Nature. 2011 Sep 28;477(7366):611-5. doi: 10.1038/nature10488. PMID:21956331 doi:10.1038/nature10488
  13. Schwartz TW, Sakmar TP. Structural biology: snapshot of a signalling complex. Nature. 2011 Sep 28;477(7366):540-1. doi: 10.1038/477540a. PMID:21956322 doi:10.1038/477540a

Additional Resources that may be helpful on interesting

Workshop Session for November 8th class

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Wayne Decatur

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