Binding site of AChR

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AChR loop (pink, yellow) complex with bungarotoxin (grey, green) and I- ion (purple) (PDB code 1hc9)

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1. nAChR is...?

Dimeric ligand-gated ion channel
Trimeric ligand-gated ion channel
Tetramer ligand-gated ion channel
Pentameric ligand-gated ion channel

2. How many residues HAP has?


3. HAP is a part of AChBP


4. What will happen when αBTX binding to AChR?

The channel will open
The subunits will be locked
Nothing will happen

5. Which finger of αBTX has the shortest and most numerous interaction with HAP?


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See also:


  1. Purves, Dale, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White (2008). Neuroscience. 4th ed. Sinauer Associates. pp. 156–7. ISBN 978-0-87893-697-7.
  2. Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C. Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proc Natl Acad Sci U S A. 2013 Oct 28. PMID:24167270 doi:
  3. 3.0 3.1 3.2 3.3 3.4 Bocquet N, Nury H, Baaden M, Le Poupon C, Changeux JP, Delarue M, Corringer PJ. X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature. 2009 Jan 1;457(7225):111-4. Epub 2008 Nov 5. PMID:18987633 doi:10.1038/nature07462
  4. 4.0 4.1 4.2 4.3 4.4 Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 2001 Oct 25;32(2):265-75. PMID:11683996
  5. 5.0 5.1 5.2 Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature. 2001 May 17;411(6835):269-76. PMID:11357122 doi:10.1038/35077011
  7. Samson AO, Levitt M. Inhibition mechanism of the acetylcholine receptor by alpha-neurotoxins as revealed by normal-mode dynamics. Biochemistry. 2008 Apr 1;47(13):4065-70. doi: 10.1021/bi702272j. Epub 2008 Mar 8. PMID:18327915 doi:

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Ma Zhuang, Zicheng Ye, Angel Herraez, Alexander Berchansky, Michal Harel

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