C-Myc

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3D structures of C-myc

Updated on 06-July-2020

2a93 – Cmyc-Max leucine zipper – synthetic – NMR
2ap2 – sCmyc + antibody
5i4z - hCmyc bHLHZ domain - human
5i50 - hCmyc bHLHZ domain + DNA
6g6j, 6g6k, 6g6l – hCmyc + hMax
1nkp – hCmyc + hMax + DNA
1mv0 – hCmyc residues 55-68 + box-dependent-interacting protein residues 513-593 - NMR

Additional Resources

For additional information, see: Cancer
For additional information, see: Oncogenes
For additional information, see: Transcription and RNA Processing

References


Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. Molecular and Cellular Biology, 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. Cell, 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

Gardner, Lee, & Dang (2002) The c-Myc Oncogenic Transcription Factor. [1]

Dose et al., (2006) C-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood. 108: 2669-2677.

Gilbert, S.F. http://8e.devbio.com/article.php?ch=5&id=42. September 21,2009.

C-myc gene found to play role in immune system. The Medical News. [2]

Davis AC, Wims M, Spotts GD, Hann SR, Bradley A. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes & Development 1993 Apr;7(4):671-82

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