C-di-GMP specific phosphodiesterases

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C-di-GMP specific phosphodiesterase complex with guanosine-5-monophosphate (stick model) and Ca+2 ions (green) (PDB code 2w27)

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3D structure of C-di-GMP phosphodiesterase



YkuI structure 2w27:

  • Minasov G, Padavattan S, Shuvalova L, Brunzelle JS, Miller DJ, Basle A, Massa C, Collart FR, Schirmer T, Anderson WF. Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains. J Biol Chem. 2009 May 8;284(19):13174-84. Epub 2009 Feb 24. PMID:19244251 doi:10.1074/jbc.M808221200

BlrP1 structure 3gg0:

  • Barends TR, Hartmann E, Griese JJ, Beitlich T, Kirienko NV, Ryjenkov DA, Reinstein J, Shoeman RL, Gomelsky M, Schlichting I. Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase. Nature. 2009 Jun 18;459(7249):1015-8. PMID:19536266 doi:10.1038/nature07966

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Michal Harel, Joel L. Sussman, Alexander Berchansky, Tilman Schirmer

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