CD1

From Proteopedia

Jump to: navigation, search


CD1 (or Cluster of Differentiation 1 or T-cell surface glycoprotein CD1 or antigen-presenting glycoprotein CD1) is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.[1]

  • Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid (PDB entry 3ilp).[2]

Structure of mouse CD1 extracellular domain (magenta) containing β-microglobulin (green) complex with glycolipid (PDB entry 3ilp)

Drag the structure with the mouse to rotate

3D Structures of CD1

Updated on 15-November-2022

CD1 or T-cell surface glycoprotein CD1
CD1 complex with glycolipid
CD1 complex with glycolipid and T-cell receptor (TCR) protein

References

  1. ↑ Zajonc DM, Wilson IA. Architecture of CD1 proteins. Curr Top Microbiol Immunol. 2007;314:27-50. PMID:17593656
  2. ↑ Wang J, Li Y, Kinjo Y, Mac TT, Gibson D, Painter GF, Kronenberg M, Zajonc DM. Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A. 2009 Dec 30. PMID:20080535

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://proteopedia.org/wiki/index.php/CD1"
Personal tools