Calcineurin

From Proteopedia

1 Function
2 Relevance
3 Structural highlights
4 3D structures of calcineurin

Function

Calcineurin (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. For more details see Group:MUZIC:Calcineurin.

Relevance

CN inhibitors are used as drugs in cases of rheumatic diseases, schizophrenia and diabetes. It is inhibited by immunosuppressant drugs like cyclosporine.

Structural highlights

It contains a calmodulin-binding catalytic subunit A and a Ca+2-binding regulatory subunit B. There are 2 metal ions in CN active site (molecules of water are shown as red spheres).^[1]

3D structures of calcineurin

Calcineurin 3D structures

Human calcineurin regulatory subunit B (magenta) and catalytic subunit A (cyan) complex with Ca+2 (green), Fe +3 (orange) and Zn+2 (grey) ions, 1aui

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References

↑ Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al.. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1995 Dec 7;378(6557):641-4. PMID:8524402 doi:http://dx.doi.org/10.1038/378641a0

See Group:MUZIC:Calcineurin.