Chemotaxis protein

From Proteopedia

E. coli CheY (PDB entry 1e6m) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Chemotaxis proteins direct cell movement according to certain chemicals in their environment.[1] CheY is a response regulator determining the swimming behaviour of the cell[2]. CheR is a SAM-dependent methyltransferase which binds to the C-terminus of some chemotaxis receptors and methylates neighbouring receptor molecules[3]. See Molecular Playground/CheR and Chemotaxis receptor methyltransferase. CheA is a histidine kinase which donates phosphoric groups to CheB and CheY to control swimming behaviour[4]. See Molecular Playground/CheA. CheB is a methyltransferase catalysing the demethylationof chemotaxis membrane receptors in Salmonella typhimurium[5]. CheW participates in the control of CheA activity[6]. See Molecular Playground/Bacterial Chemotaxis Receptors Aspartate chemotaxis receptor or Tar modulates the activity of CheA[7]. See DNA Origami Assembly for the Tar Chemoreceptor. Methyl-accepting chemotaxis protein are the predominant chemoreceptors in bacteria and archaea. They are involved in regulation of diverse aspects of cellular activities[8]. See Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor. FLiN and MotB are involved in energizing flagellar rotation in E. coli[9]. CKI1 is a histidine kinase involved in cytokinin signal transduction[10]. See Receiver domain of sensor histidine kinase CKI1. See also: Molecular Playground/Cytoplasmic domain of chemoreceptor of Thermotoga maritima 3D structures of chemotaxis protein Chemotaxis protein 3D structures

References

1. ↑ Adler J, Tso WW. "Decision"-making in bacteria: chemotactic response of Escherichia coli to conflicting stimuli. Science. 1974 Jun 21;184(4143):1292-4. PMID:4598187
2. ↑ Sanna MG, Swanson RV, Bourret RB, Simon MI. Mutations in the chemotactic response regulator, CheY, that confer resistance to the phosphatase activity of CheZ. Mol Microbiol. 1995 Mar;15(6):1069-79. PMID:7623663 doi:10.1111/j.1365-2958.1995.tb02282.x
3. ↑ Djordjevic S, Stock AM. Chemotaxis receptor recognition by protein methyltransferase CheR. Nat Struct Biol. 1998 Jun;5(6):446-50. PMID:9628482
4. ↑ Jahreis K, Morrison TB, Garzón A, Parkinson JS. Chemotactic signaling by an Escherichia coli CheA mutant that lacks the binding domain for phosphoacceptor partners. J Bacteriol. 2004 May;186(9):2664-72. PMID:15090507 doi:10.1128/JB.186.9.2664-2672.2004
5. ↑ Simms SA, Keane MG, Stock J. Multiple forms of the CheB methylesterase in bacterial chemosensing. J Biol Chem. 1985 Aug 25;260(18):10161-8. PMID:2991277
6. ↑ Gegner JA, Dahlquist FW. Signal transduction in bacteria: CheW forms a reversible complex with the protein kinase CheA. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):750-4. PMID:1992467 doi:10.1073/pnas.88.3.750
7. ↑ Tatsuno I, Homma M, Oosawa K, Kawagishi I. Signaling by the Escherichia coli aspartate chemoreceptor Tar with a single cytoplasmic domain per dimer. Science. 1996 Oct 18;274(5286):423-5. PMID:8832891 doi:10.1126/science.274.5286.423
8. ↑ Salah Ud-Din AIM, Roujeinikova A. Methyl-accepting chemotaxis proteins: a core sensing element in prokaryotes and archaea. Cell Mol Life Sci. 2017 Sep;74(18):3293-3303. PMID:28409190 doi:10.1007/s00018-017-2514-0
9. ↑ Garza AG, Harris-Haller LW, Stoebner RA, Manson MD. Motility protein interactions in the bacterial flagellar motor. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1970-4. PMID:7892209 doi:10.1073/pnas.92.6.1970
10. ↑ Kakimoto T. CKI1, a histidine kinase homolog implicated in cytokinin signal transduction. Science. 1996 Nov 8;274(5289):982-5. PMID:8875940