Circadian clock protein

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Circadian clock proteins or Circadian clock protein kinase measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA[1] stimulates KaiC[2] which adds phosphate groups to itself. Then KaiC binds to KaiB[3] which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.[4] For details of KaiC see Circadian Clock Protein KaiC.

Circadian clock protein KaiA from Synechococcus elongatus is homodimer (PDB entry 1r8j).

3D Structures of circadian clock protein

Circadian clock protein 3D structures


Circadian clock protein KaiA (PDB entry 1r8j)

Drag the structure with the mouse to rotate

References

  1. ↑ Ye S, Vakonakis I, Ioerger TR, LiWang AC, Sacchettini JC. Crystal structure of circadian clock protein KaiA from Synechococcus elongatus. J Biol Chem. 2004 May 7;279(19):20511-8. Epub 2004 Mar 8. PMID:15007067 doi:10.1074/jbc.M400077200
  2. ↑ Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M. Visualizing a circadian clock protein: crystal structure of KaiC and functional insights. Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218 doi:10.1016/j.molcel.2004.07.013
  3. ↑ . PMID:15716247
  4. ↑ Harmer SL, Panda S, Kay SA. Molecular bases of circadian rhythms. Annu Rev Cell Dev Biol. 2001;17:215-53. PMID:11687489 doi:http://dx.doi.org/10.1146/annurev.cellbio.17.1.215

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