Epidermal growth factor

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Function

Epidermal growth factor (EGF) plays a role in cell growth. It binds to its receptor (EGFR). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity.[1] Some details
on EGF exon in EGF1
on Gla domain in Gla domain
Pre-prozymogen.

Relevance

EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination.

Structural highlights

All EGF family proteins contain a conserved amino acid sequence which includes 3 disulfide bonds (PDB code 1jl9).[2]

Dimer of the monomeric human epidermal growth factor (PDB code 1jl9)

Drag the structure with the mouse to rotate

3D structures of epidermal growth factor

Updated on 23-February-2023

EGF
Heparin-binding EGF-like growth factor
EGF-like Cripto protein

References

  1. ↑ Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem. 1990 May 15;265(14):7709-12. PMID:2186024
  2. ↑ Lu HS, Chai JJ, Li M, Huang BR, He CH, Bi RC. Crystal structure of human epidermal growth factor and its dimerization. J Biol Chem. 2001 Sep 14;276(37):34913-7. Epub 2001 Jul 3. PMID:11438527 doi:10.1074/jbc.M102874200

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Michal Harel, Alexander Berchansky

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